Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
-
Product Description
-
Seller Information
-
Description
ProductName PQ 401 Cat No CEI-0882 Description PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM. CAS No 196868-63-0 Molecular Weight 341.79 Storage 2 years -20 centigrade Powder; 2 weeks 4 centigrade in DMSO; 6 months -80 centigrade in DMSO. Targets IGF-1R IC50 <1 μM Molecular Formula C18H16ClN3O2 Chemical Name N-(5-chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)- Solubility DMSO 32 mg/mL; Water <1 mg/mL; Ethanol <1 mg/mL In vitro PQ 401 is an IGF-1R inhibitor and inhibits autophosphorylation of the IGF-IR kinase domain at concentrations <100 nM, with an IC50 <1μM. PQ 401 significantly reduced proliferation of MCF-7 cells with IC50 of 8 μM. PQ 401 also inhibits growth of MCNeuA cells with IC50 of 15 μM. PQ 401 inhibits the IGF-I-mediated antiapoptotic pathway in MCF-7 cells. PQ 401 increases caspase-mediated apoptotic activity in MCF-7 cells. In vivo PQ 401 (50 mg/Kg, 100 mg/Kg) significantly inhibits MCNeuA tumor growth in a dose-dependent manner. category Inhibitors(c1514) cas_num 196868-63-0 Basic Info-
Product Name:
IGF-1RInhibitorII,N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea
Other Name:IGF-1RInhibitorII,N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea;PQ401;N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)urea;IGF-1R Inhibitor II;N-(5-Chloro-2-methoxyphenyl)-N′-(2-methylquinolin-4-yl)urea;Urea, N-(5-chloro-2-Methoxyphenyl)-N'-(2-Methyl-4-quinolinyl)-;1-(5-Chloro-2-Methoxyphenyl)-3-(2-Methylquinolin-4-yl)urea;N-(5-chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)-
CAS No.:196868-63-0
Molecular Formula:C18H16ClN3O2
InChIKeys:YBLWOZUPHDKFOT-UHFFFAOYSA-N
Molecular Weight:341.796
Exact Mass:341.093109
HScode:2933499090
Categories:
Characteristics-
PSA:
63.25000
XLogP3:5.35
Appearance:white
Density:1.4±0.1 g/cm3
Boiling Point:426.1±45.0 °C at 760 mmHg
Flash Point:211.5±28.7 °C
Refractive Index:1.709
Water Solubility:DMSO: >10mg/mL
Storage Conditions:2-8°C
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 3, Oral
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H301 Toxic if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
-
-
Seller Information
-
Business Type:
Manufactory
-
Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
-
Location:
Shirley, New York 11967, USA
-
Payment Terms:
TT against copy of documents,D/P
-
Average lead Time:
15
-
Total Annual Revenue:
$1 million-$2.5 million
-
Year of Establishment:
2004
-
-
Country Product Purchase Quantity Date Posted Post an enquiry for this product