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XL-388

XL-388 structure

CAS No:
1251156-08-7
Formula:
C23H22FN3O4S
Chemical Name:
XL-388
Synonyms:
Methanone, [7-(6-amino-3-pyridinyl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl][3-fluoro-2-methyl-4-(methylsulfonyl)phenyl]-;[7-(6-Amino-3-pyridinyl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl][3-fluoro-2-methyl-4-(methylsulfonyl)phenyl]-methanone XL388;XL388, >=98%;(7-(6-Aminopyridin-3-yl)-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)(3-fluoro-2-methyl-4-(methy;XL 388;XL388;XL-388;[7-(6-Amino-3-pyridinyl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl][3-fluoro-2-methyl-4-(methylsulfonyl)phenyl]-methanone
Categories:
Biochemical Engineering > Inhibitors

Description

XL388 is a highly potent and ATP-competitive mTOR inhibitor with an IC50 of 9.9 nM. XL388 simultaneously inhibits both mTORC1 and mTORC2.

XL-388 Basic Attributes

Molecular Weight：

455.5018832

Exact Mass：

455.131500

UNII：

B7I5G3Z7XR

Characteristics

PSA：

111

XLogP3：

2.5

Density：

1.354±0.06 g/cm3(Predicted)

Boiling Point：

738.6±60.0 °C(Predicted)

Flash Point：

400.5±32.9 °C

Refractive Index：

1.619

Drug Information

MeSH Entry Terms：

XL388

Computed Properties

Molecular Weight:455.5
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:455.13150553
Monoisotopic Mass:455.13150553
Topological Polar Surface Area:111
Heavy Atom Count:32
Complexity:776
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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XL388

CAS No.: 1251156-08-7

Content: 0.98%

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