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GSK-2110183C

GSK-2110183C structure

CAS No:
1047644-62-1
Formula:
C18H17Cl2FN4OS
Chemical Name:
GSK-2110183C
Synonyms:
Afuresertib;GSK 2110183C;GSK2110183C;GSK-2110183C;N-((S)-1-amino-3-(3-fluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxamide;Afuresertib(GSK2110183C);Afuresertib,GSK-2110183, GSK-2110183B;Delitinib
Categories:
Biochemical Engineering > Inhibitors

Description

N-[(2S)-1-amino-3-(3-fluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methyl-3-pyrazolyl)-2-thiophenecarboxamide is a member of amphetamines.|Afuresertib has been used in trials studying the treatment of Cancer and Neoplasms, Haematologic.|Afuresertib is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Afuresertib binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

GSK-2110183C Basic Attributes

Molecular Weight：

427.319

Exact Mass：

426.048

EC Number：

1592732-453-0

UNII：

8739X25QI3

DSSTox ID：

DTXSID60146711

NCI Thesaurus Code：

C82390

Characteristics

PSA：

101

XLogP3：

Drug Information

MeSH Entry Terms：

afuresertib

Computed Properties

Molecular Weight:427.3
XLogP3:4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:426.0484159
Monoisotopic Mass:426.0484159
Topological Polar Surface Area:101
Heavy Atom Count:27
Complexity:520
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes