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CAY10603

CAY10603 structure

CAS No:
1045792-66-2
Formula:
C22H30N4O6
Chemical Name:
CAY10603
Synonyms:
CAY10603;Isox;tert-butyl 4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenylcarbamate;HDAC6 Inhibitor;N-[4-[3-[[[7-(Hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]carbamic acid 1,1-dimethylethyl ester;HDAC6 inhibitor ISOX
Categories:
Biochemical Engineering > Inhibitors

Description

CAY10603 is a potent and selective HDAC6 inhibitor, with an IC50 of 2 pM; CAY10603 also inhibits HDAC1, HDAC2, HDAC3, HDAC8, HDAC10, with IC50s of 271, 252, 0.42, 6851, 90.7 nM.

N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]-oxomethyl]-5-isoxazolyl]phenyl]carbamic acid tert-butyl ester is a carbamate ester.

CAY10603 Basic Attributes

Molecular Weight：

446.504

Exact Mass：

446.216522

DSSTox ID：

DTXSID70648059

Characteristics

PSA：

143

XLogP3：

2.6

Density：

1.231±0.06 g/cm3(Predicted)

Refractive Index：

1.563

Drug Information

MeSH：

Compounds that inhibit HISTONE DEACETYLASES. This class of drugs may influence gene expression by increasing the level of acetylated HISTONES in specific CHROMATIN domains. (See all compounds classified as Histone Deacetylase Inhibitors.)

MeSH Entry Terms：

CAY10603

Computed Properties

Molecular Weight:446.5
XLogP3:2.6
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:12
Exact Mass:446.21653469
Monoisotopic Mass:446.21653469
Topological Polar Surface Area:143
Heavy Atom Count:32
Complexity:616
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 1045792-66-2

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