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LMK-235

LMK-235 structure

CAS No:
1418033-25-6
Formula:
C15H22N2O4
Chemical Name:
LMK-235
Synonyms:
LMK-235;N-[[6-(Hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethyl-benzamide;N-[[6-(Hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethylbenzamide LMK-235
Categories:
Biochemical Engineering > Inhibitors

Description

LMK-235 is a potent and selective HDAC4/5 inhibitor, inhibits HDAC5, HDAC4, HDAC6, HDAC1, HDAC2, HDAC11 and HDAC8, with IC50s of 4.22 nM, 11.9 nM, 55.7 nM, 320 nM, 881 nM, 852 nM and 1278 nM, respectively, and is used in cancer research.

LMK-235 Basic Attributes

Molecular Weight：

294.34618

Exact Mass：

294.157959

EC Number：

-0

Characteristics

PSA：

87.7

XLogP3：

1.8

Appearance：

white to beige

Density：

1.2±0.1 g/cm3

Refractive Index：

1.538

Water Solubility：

DMSO: soluble20mg/mL, clear

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

Marks：

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 127 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Compounds that inhibit HISTONE DEACETYLASES. This class of drugs may influence gene expression by increasing the level of acetylated HISTONES in specific CHROMATIN domains. (See all compounds classified as Histone Deacetylase Inhibitors.)

MeSH Entry Terms：

Benzamide, N-((6-(hydroxyamino)-6-oxohexyl)oxy)-3,5-dimethyl-

Computed Properties

Molecular Weight:294.35
XLogP3:1.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:294.15795719
Monoisotopic Mass:294.15795719
Topological Polar Surface Area:87.7
Heavy Atom Count:21
Complexity:326
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes