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GSK2636771

GSK2636771 structure

CAS No:
1372540-25-4
Formula:
C22H22F3N3O3
Chemical Name:
GSK2636771
Synonyms:
GSK2636771;2-Methyl-1-[[2-Methyl-3-(trifluoroMethyl)phenyl]Methyl]-6-(4-Morpholinyl)-1H-benziMidazole-4-carboxylic acid;GSK2636771/GSK-2636771;1H-Benzimidazole-4-carboxylic acid, 2-methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-6-(4-morpholinyl)-;2-Methyl-1-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylic acidGSK2636771;GSK 2636771 dihydrochloride;2-Methyl-1-(2-methyl-3-(trifluoromethyl)benzyl)-6-morpholino-1H-benzo[d]imidazole-4-carboxylic;2-METHYL-1-[[2-METHYL-3-(TRIFLUOROMETHYL)PHENYL]METHYL]-6-MORPHOLIN-4-YLBENZIMIDAZOLE-4-CARBOXYLIC ACID
Categories:
Biochemical Engineering > Inhibitors

Description

GSK2636771 is a potent, selective and oral inhibitor of PI3Kβ with a Ki of 0.89 nM and an IC50 of 5.2 nM, showing 900-fold selectivity over p110α and p110γ, and 10-fold selectivity over p110δ isoforms.

GSK2636771 Basic Attributes

Molecular Weight：

433.4235896

Exact Mass：

433.161316

Characteristics

PSA：

67.6

XLogP3：

3.61

Density：

1.38

Boiling Point：

641.3±55.0 °C(Predicted)

Flash Point：

341.7±31.5 °C

Refractive Index：

1.606

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GSK2636771

CAS No.: 1372540-25-4

Content: 99.00%

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CAS No.: 1372540-25-4

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