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GSK1070916

GSK1070916 structure

CAS No:
942918-07-2
Formula:
C30H33N7O
Chemical Name:
GSK1070916
Synonyms:
N'-[4-[4-[2-[3-[(Dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-1H-pyrazol-3-yl]phenyl]-N,N-dimethylurea;GSK1070916;3-(4-(4-(2-(3-((Dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea;N'-[4-[4-[2-[3-[(DiMethylaMino)Methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-1H-pyrazol-3-yl;GSK-1070916A
Categories:
Biochemical Engineering > Inhibitors

Description

GSK-1070916 is a potent and selective ATP-competitive inhibitor of aurora B and aurora C with Kis of 0.38 and 1.5 nM, respectively, and is >250- fold selective over Aurora A.

3-[4-[4-[2-[3-[(dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-3-pyrazolyl]phenyl]-1,1-dimethylurea is a member of pyrazoles and a ring assembly.

GSK1070916 Basic Attributes

Molecular Weight：

507.63

Exact Mass：

507.274658

UNII：

8VLB51V7HO

DSSTox ID：

DTXSID70241403

Characteristics

PSA：

82.1

XLogP3：

5.19

Density：

1.2±0.1 g/cm3

Refractive Index：

1.651

Drug Information

MeSH Entry Terms：

4-(3-(4-N,N-dimethylcarbamylaminophenyl)-1-ethyl-1H-pyrazol-4-yl)-2-(3-(dimethylaminomethyl)phenyl)-1H-pyrrolo(2,3-b)pyridine

Computed Properties

Molecular Weight:507.6
XLogP3:3.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:507.27465870
Monoisotopic Mass:507.27465870
Topological Polar Surface Area:82.1
Heavy Atom Count:38
Complexity:770
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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GSK1070916

CAS No.: 942918-07-2

Content: 0.98%

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