2-Chloro-5-nitrobenzanilide
-
2-Chloro-5-nitrobenzanilide
structure -
-
CAS No:
22978-25-2
-
Formula:
C13H9ClN2O3
-
Chemical Name:
2-Chloro-5-nitrobenzanilide
-
Synonyms:
Benzamide,2-chloro-5-nitro-N-phenyl-;Benzanilide,2-chloro-5-nitro-;2-Chloro-5-nitro-N-phenylbenzamide;2-Chloro-5-nitrobenzanilide;GW 9662;GW 9622
- Categories:
-
CAS No:
Description
GW9662 is a potent and selective PPARγ antagonist with an IC50 of 3.3 nM, showing 10 and 1000-fold selectivity over PPARα and PPARδ, respectively.
GW 9662 is a member of benzamides.
2-Chloro-5-nitrobenzanilide Basic Attributes
276.68
276.68
1592732-453-0
UM18UZV2YD
DTXSID8040723
2924299090
Characteristics
74.9
3.3
white solid
1.4±0.1 g/cm3
158 °C
360.9±32.0°C at 760 mmHg
172.0±25.1 °C
1.676
DMSO: 26 mg/mL, soluble
2-8°C
2.15E-05mmHg at 25°C
Safety Information
NONH for all modes of transport
3
36-43
26-36/37-24/25-22
Xi
P280-P305 + P351 + P338
H317-H319
|Warning|H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]|P261, P264, P272, P280, P302+P352, P305+P351+P338, P321, P333+P313, P337+P313, P363, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
2-Chloro-5-nitrobenzanilide Use and Manufacturing
A cell-permeable, selective and irreversible PPAR antagonist (IC50 = 3.3 nM, 32 nM, and 2for PPAR, PPARa, and PPARd, respectively). Reported to covalently modify a cysteine residue in the binding site of PPAR. At a concentration of 10 , also
Computed Properties
Molecular Weight:276.67
XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:276.0301698
Monoisotopic Mass:276.0301698
Topological Polar Surface Area:74.9
Heavy Atom Count:19
Complexity:339
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 2-Chloro-5-nitrobenzanilide
-
![United States]()
US
6 YRS
Business licensed Certified factoryManufactory Supplier of Coenzymes,Inhibito,Enzymes,Zymogens,Substrates -
![China]()
CN
4 YRS
Business licensedTrader Supplier of API OLED Organic intermediate -
![China]()
CN
2 YRS
Business licensed Certified factoryManufactory Supplier of AEEA-AEEA,Fmoc-AEEA,Fmoc-Lys(Alloc)-OHInquiryCAS No.: 22978-25-2Grade: Industrial GradeContent: 90%
Latest News on 2-Chloro-5-nitrobenzanilide
- BMS Over $900 Million to Help Develop Potential 'Best-in-class' SHP2 Inhibitors
- AbbVie's blockbuster product for atopic dermatitis, Upadacitinib, has been approved for marketing in the EU and Japan
- Designing peptide inhibitors for possible COVID-19 treatments
- Chinese scientists discover the inhibitors of SARS-CoV-2
Learn More Other Chemicals
-
Dabrafenib
1195765-45-7
-
BOC-VAL-VAL-OH
69209-73-0
-
BMS 303141
943962-47-8
-
(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanamide Formula
60117-17-1
-
(2S)-2-acetamido-6-amino-N-[(2S)-2-amino-3-methylbutanoyl]-N-propylhexanamide Formula
57899-96-4
-
1-(6-methoxy-1,3-benzothiazol-2-yl)-3-phenylurea Formula
26130-02-9
-
L-Tyrosyl-L-phenylalanine Structure
17355-11-2
-
C-REACTIVE PROTEIN FRAGMENT 77-82 Structure
130349-01-8
-
What is Sildenafil
139755-83-2
-
What is Dacomitinib
1110813-31-4