 Home > Encyclopedia > Sirtinol

Sirtinol

Sirtinol structure

CAS No:
410536-97-9
Formula:
C26H22N2O2
Chemical Name:
Sirtinol
Synonyms:
Benzamide,2-[[(2-hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)-;2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide;Sirtinol;S 2804
Categories:
Biochemical Engineering > Inhibitors

Description

Sirtinol is a sirtuin inhibitor, with IC50s of 48 μM, 57.7 μM and 131 μM for ySir2, hSIRT2 and hSIRT2, respectively.

Sirtinol is a benzamide obtained by formal condensation of the carboxy group of 2-{[(2-hydroxy-1-naphthyl)methylene]amino}benzoic acid with the amino group of 1-phenylethylamine. It has a role as an anti-inflammatory agent, an EC 3.5.1.98 (histone deacetylase) inhibitor and a Sir2 inhibitor. It is a member of benzamides, an aldimine and a member of naphthols. It derives from an anthranilic acid.

Sirtinol Basic Attributes

Molecular Weight：

394.47

Exact Mass：

394.47

HScode：

2925290090

Characteristics

PSA：

61.69000

XLogP3：

6.17790

Density：

1.2±0.1 g/cm3

Melting Point：

119-120 °C @ Solvent: Acetonitrile

Boiling Point：

650°C at 760 mmHg

Flash Point：

352.5±30.1 °C

Refractive Index：

1.623

Water Solubility：

soluble in water, DMSO and methanol

Storage Conditions：

−20°C

Safety Information

wgk germany：

Drug Information

MeSH Entry Terms：

sirtinol

Sirtinol Use and Manufacturing

Sirtinol is a known inhibitor of the NAD+-Dependent Protein Desuccinylase and Demalonylase Sirt5 and exhibits anticancer properties.

Computed Properties

Molecular Weight:394.5
XLogP3:5.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:394.168127949
Monoisotopic Mass:394.168127949
Topological Polar Surface Area:61.7
Heavy Atom Count:30
Complexity:586
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Sirtinol

Creative Enzymes Contact Supplier

US
6 YRS

Business licensed Certified factory

Manufactory Supplier of Coenzymes,Inhibito,Enzymes,Zymogens,Substrates

Sirtinol

CAS No.: 410536-97-9

Content: 98%

Inquiry