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PF-04929113

PF-04929113 structure

CAS No:
908115-27-5
Formula:
C25H30F3N5O4
Chemical Name:
PF-04929113
Synonyms:
(1r,4r)-4-(2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydroindazol-1-yl)phenylamino)cyclohexyl 2-aminoacetate;PF-04929113, >=98%;snx54227;PF04929113 SNX-54227;PF-04929113;SNX-5422;PF-04929113(SNX5422);Glycine trans-4-[[2-(aminocarbonyl)-5-[4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-3-(trifluoromethyl)-1H-indazol-1-yl]phenyl]amino]cyclohexyl ester
Categories:
Biochemical Engineering > Inhibitors

Description

SNX-5422 (PF-04929113), a prodrug of SNX-2112, is an orally active Hsp90 inhibitor, with a Kd of 41 nM, and also induces Her-2 degradation, with an IC50 of 37 nM.

SNX-5422 is a synthetic, novel, small molecule Hsp90 Inhibitor. As an oral formulation that demonstrates strong efficacy and tolerability, SNX-5422 is positioned as a breakthrough therapy with broad applicability across a wide range of cancers.

PF-04929113 Basic Attributes

Molecular Weight：

521.5320096

Exact Mass：

521.224976

UNII：

BF52J69Q8T

DSSTox ID：

DTXSID50238270

Characteristics

PSA：

142

XLogP3：

3.38

Density：

1.5±0.1 g/cm3

Melting Point：

298-299℃

Boiling Point：

646.5±55.0 °C at 760 mmHg

Flash Point：

344.8±31.5 °C

Refractive Index：

1.637

Drug Information

Drug Indication：

Investigated for use/treatment in cancer/tumors (unspecified).

Pharmacology：

SNX-5422 is under development by Serenex. It is orally administered (pill form). Once in the body, SNX-5422 is converted to SNX-2122; that is, SNX-5422 is a prodrug of SNX-2112, which is the active form.

Mechanism of Action：

SNX-5422 is a direct, potent inhibitor of Hsp90 across a broad range of human cancer cell lines and causes degradation of important Hsp90 client proteins including HER2, AKT and ERK.

MeSH Entry Terms：

glycine trans-4-((2-(aminocarbonyl)-5-(4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-3-(trifluoromethyl)-1H-indazol-1-yl)phenyl)amino)cyclohexyl ester

Computed Properties

Molecular Weight:521.5
XLogP3:3.5
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:7
Exact Mass:521.22498894
Monoisotopic Mass:521.22498894
Topological Polar Surface Area:142
Heavy Atom Count:37
Complexity:877
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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PF-04929113(SNX-5422)

CAS No.: 908115-27-5

Content: 99%

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