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Src kinase inhibitor PP2

Src kinase inhibitor PP2 structure

CAS No:
172889-27-9
Formula:
C15H16ClN5
Chemical Name:
Src kinase inhibitor PP2
Synonyms:
1H-Pyrazolo[3,4-d]pyrimidin-4-amine,3-(4-chlorophenyl)-1-(1,1-dimethylethyl)-;3-(4-Chlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;PP 2;PP 2 (enzyme inhibitor);AGL 1879;Src kinase inhibitor PP2;1-tert-Butyl-3-(4-chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-amine;4-Amino-3-(4-chlorophenyl)-1-(t-butyl)-1H-pyrazolo[3,4-d]pyrimidine;882691-93-2
Categories:
Biochemical Engineering > Inhibitors

Description

PP2 is a reversible and ATP-competitive Src family kinases inhibitor with IC50s of 4 and 5 nM for Lck and Fyn, respectively.

PP2 is a member of the class of pyrazolopyrimidine that is pyrazolo[3,4-d]pyrimidin-4-amine bearing additional tert-butyl and 4-chlorophenyl substituents at positions 1 and 3 respectively. It is a potent ATP-competitive inhibitor of the Src family of protein tyrosine kinases. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, a beta-adrenergic antagonist and a geroprotector. It is a pyrazolopyrimidine, an aromatic amine and a member of monochlorobenzenes.

Src kinase inhibitor PP2 Basic Attributes

Molecular Weight：

301.77

Exact Mass：

301.77

DSSTox ID：

DTXSID60274447

HScode：

2933990090

Characteristics

PSA：

69.6

XLogP3：

Appearance：

White solid

Density：

1.35±0.1 g/cm3(Predicted)

Melting Point：

214-216ºC

Boiling Point：

493.5±40.0 °C(Predicted)

Flash Point：

252.3±27.3 °C

Refractive Index：

1.676

Storage Conditions：

Desiccate at +4°C

Vapor Pressure：

6.98E-10mmHg at 25°C

Safety Information

Transport codes：

UN 2811 6.1 / PGIII

hazard class code：

safety instructions：

Marks：

Drug Information

MeSH Entry Terms：

4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo(3,4-d)pyrimidine

Src kinase inhibitor PP2 Use and Manufacturing

Selective inhibitor of Src-family tyrosine kinases. Inhibits p56 lck and p59 fynT (IC 50 values are 4 and 5 nM respectively). Displays > 10000-fold selectivity over ZAP-70 and JAK2. Moderately inhibits CSK (IC 50 = 0.73 μ M).This cell-permeable and photosensitive ATP site-directed pyrazolepyrimidine (FW = 301.78 g/mol), also known as 4-amino-5-(4- chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine and tyrphostin AG 1879, potently inhibits Lck and Fyn protein kina

Computed Properties

Molecular Weight:301.77
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:301.1094232
Monoisotopic Mass:301.1094232
Topological Polar Surface Area:69.6
Heavy Atom Count:21
Complexity:364
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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1H-Pyrazolo[3,4-d]pyrimidin-4-amine,3-(4-chlorophenyl)-1-(1,1-dimethylethyl)-

CAS No.: 172889-27-9

Content: 99.00%

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