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Tie2 kinase inhibitor

Tie2 kinase inhibitor structure

CAS No:
948557-43-5
Formula:
C26H21N3O2S
Chemical Name:
Tie2 kinase inhibitor
Synonyms:
4-(6-Methoxy-2-naphthyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole;Tie2 kinase inhibitor;4-[4-(6-Methoxy-2-naphthalenyl)-2-[4-(Methylsulfinyl)phenyl]-1H-iMidazol-5-yl]pyridine;4-(5-(6-methoxynaphthalen-2-yl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-4-yl)pyridine
Categories:
Biochemical Engineering > Inhibitors

Description

Tie2 kinase inhibitor 1 (compound 5) is a potent, selective Tie2 kinase inhibitor with an IC50 of 250 nM[1]. Tie2 kinase inhibitor 1 has anti-cancer activity[2].

Tie2 kinase inhibitor Basic Attributes

Molecular Weight：

439.52884

Exact Mass：

439.135437

Characteristics

PSA：

87.1

XLogP3：

4.3

Density：

1.4±0.1 g/cm3

Boiling Point：

699.8±55.0°C at 760 mmHg

Flash Point：

377.0±31.5 °C

Refractive Index：

1.746

Tie2 kinase inhibitor Use and Manufacturing

Tunica interna endothelial cell kinase 2 (Tie2, also known as angiopoietin-1 receptor or tek) is an endothelium-specific receptor tyrosine kinase important for the development of embryonic vasculature and for angiogenesis and vascular maintenance in adult tissues. Tie2 kinase inhibitor reversibly and selectively blocks Tie2 kinase activity with an IC50 value of 250 nM. It is 200-fold more potent for inhibition of Tie2 compared to p38. Tie2 kinase inhibitor has been shown to reduce angiogenesis in a Matrigel neovascularization assay and to delay tumor growth in MOPC-315 plasmacytoma and SVR angiosarcoma xenograft models.[Cayman Chemical]

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Tie2 kinase inhibitor

CAS No.: 948557-43-5

Content: 99%

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