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Batimastat

Batimastat structure

CAS No:
130370-60-4
Formula:
C23H31N3O4S2
Chemical Name:
Batimastat
Synonyms:
Butanediamide,N4-hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]-,(2R,3S)-;Butanediamide,N4-hydroxy-N1-[2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]-,[2R-[1(S*),2R*,3S*]]-;(2R,3S)-N4-Hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide;BB 94;Batimastat;(2S,3R)-5-Methyl-3-[[(αS)-α-(methylcarbamoyl)phenethyl]carbamoyl]-2-[(2-thienylthio)methyl]hexanohydroxamic acid
Categories:
Biochemical Engineering > Inhibitors

Description

Batimastat is a potent broad spectrum MMP inhibitor with IC50 of 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3, respectively.

Batimastat Basic Attributes

Molecular Weight：

477.64

Exact Mass：

477.64

HScode：

29349990

Characteristics

PSA：

161

XLogP3：

3.53

Appearance：

white to tan

Density：

1.3±0.1 g/cm3

Melting Point：

236-238 °C

Refractive Index：

1.605

Water Solubility：

DMSO: ≥15mg/mL

Storage Conditions：

Store at -20°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

Batimastat Use and Manufacturing

Antineoplastic.Potent, broad spectrum matrix metalloprotease (MMP) inhibitor (IC 50 values are 3, 4, 4, 6 and 20 nM for MMP -1, -2, -9, -7 and -3 respectively). Exhibits antiproliferative, anti-invasive and antimetastatic activity in human ovarian carcinoma xenografts in vivo. Batimastat also reduces in vivo growth of experimental hemangiomas, most probably by blocking endothelial cell recruitment by the transformed cells or by interfering with cell organ