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Z-DEVD-FMK

Z-DEVD-FMK structure

CAS No:
210344-95-9
Formula:
C30H41FN4O13
Chemical Name:
Z-DEVD-FMK
Synonyms:
Z-ASP-GLU-VAL-ASP-FLUOROMETHYLKETONE;Z-ASP(OME)-GLU(OME)-VAL-ASP(OME)-CH2F;Z-ASP(OME)-GLU(OME)-VAL-ASP(OME)-FLUOROMETHYLKETONE;Z-ASP(OME)-GLU(OME)-VAL-ASP(OME)-FMK;Z-ASP(OME)-GLU(OME)-VAL-DL-ASP(OME)-FLUOROMETHYLKETONE;Z-DEVD-FLUOROMETHYLKETONE;Z-DEVD-FMK;Z-D(OME)E(OME)VD(OME) FLUOROMETHYLKETONE
Categories:
Biochemical Engineering > Inhibitors

Description

Z-DEVD-FMK is a tetrapeptide consisting of Fmoc-L-aspartic acid 4-methyl ester, methyl L-alpha-glutamic acid 5-methyl ester, L-valine and the fluoromethyl ketone derived from the 1-carboxy group of L-aspartic acid 4-methyl ester coupled in sequence. It is a specific, irreversible caspase-3 inhibitor that also shows potent inhibition of caspase-6, caspase-7, caspase-8, and caspase-10. It has a role as an apoptosis inhibitor, an EC 3.4.22.56 (caspase-3) inhibitor and a neuroprotective agent.

Z-DEVD-FMK Basic Attributes

Molecular Weight：

684.66

Exact Mass：

668.271

Characteristics

PSA：

222

XLogP3：

0.9

Density：

1.260±0.06 g/cm3(Predicted)

Water Solubility：

DMSO/DMF: ≥20 mM

Storage Conditions：

−20°C

Safety Information

wgk germany：

Drug Information

MeSH：

Exogenous and endogenous compounds which inhibit CYSTEINE ENDOPEPTIDASES. (See all compounds classified as Cysteine Proteinase Inhibitors.)

MeSH Entry Terms：

benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone

Computed Properties

Molecular Weight:668.7
XLogP3:0.9
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:23
Exact Mass:668.27050092
Monoisotopic Mass:668.27050092
Topological Polar Surface Area:222
Heavy Atom Count:47
Complexity:1110
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Z-DEVD-FMK

CAS No.: 210344-95-9

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