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Procaspase activating compound 1

Procaspase activating compound 1 structure

CAS No:
315183-21-2
Formula:
C23H28N4O2
Chemical Name:
Procaspase activating compound 1
Synonyms:
1-Piperazineacetic acid,4-(phenylmethyl)-,2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide;1-Piperazineacetic acid,4-(phenylmethyl)-,[[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide;Procaspase activating compound 1;PAC 1
Categories:
Biochemical Engineering > Inhibitors

Description

PAC-1 is an activator of procaspase-3 induces apoptosis in cancer cells with EC50 of 2.08 μM.

PAC-1 has been used in trials studying the treatment of Lymphoma, Melanoma, Solid Tumors, Breast Cancer, and Thoracic Cancers, among others.

Procaspase activating compound 1 Basic Attributes

Molecular Weight：

392.5

Exact Mass：

392.49

UNII：

9LIS8N0B2C

NSC Number：

743444

HScode：

29335990

Characteristics

PSA：

68.17000

XLogP3：

2.65530

Appearance：

white

Density：

1.1±0.1 g/cm3

Refractive Index：

1.597

Water Solubility：

DMSO: ≥10mg/mL

Storage Conditions：

Store at +4°C

Safety Information

Packing level：

Ⅲ

Transport codes：

UN 3077

wgk germany：

hazard class code：

22-36/37/38-50/53

safety instructions：

26-36/37-60-61

Marks：

Xn,N

Precautionary statement(s)：

P261-P273-P305 + P351 + P338

Hazard Statements：

H302-H315-H319-H335-H400

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Procaspase activating compound 1 Use and Manufacturing

PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM.

Computed Properties

Molecular Weight:392.5
XLogP3:3.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:392.22122615
Monoisotopic Mass:392.22122615
Topological Polar Surface Area:68.2
Heavy Atom Count:29
Complexity:539
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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PAC-1

CAS No.: 315183-21-2

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Guide of Procaspase activating compound 1

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
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Procaspase activating compound 1

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