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Pifithrin

Pifithrin structure

CAS No:
63208-82-2
Formula:
C16H18N2OS.BrH
Chemical Name:
Pifithrin
Synonyms:
Ethanone,1-(4-methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)-,hydrobromide (1:1);Ethanone,1-(4-methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)-,monohydrobromide;Pifithrin-α;Pifithrin
Categories:
Biochemical Engineering > Inhibitors

Description

Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis.

2-(2-imino-4,5,6,7-tetrahydro-1,3-benzothiazol-3-yl)-1-(4-methylphenyl)ethanone is an aromatic ketone.

Pifithrin Basic Attributes

Molecular Weight：

367.3

Exact Mass：

366.040131

Characteristics

PSA：

74.09000

XLogP3：

4.15700

Appearance：

off-white powder

Density：

1.28g/cm3

Melting Point：

180 °C @ Solvent: Ethanol, Ethyl acetate

Boiling Point：

456.8ºC at 760 mmHg

Flash Point：

230.1ºC

Refractive Index：

1.666

Water Solubility：

DMSO: 20 mg/mL

Storage Conditions：

−20°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

Drug Information

MeSH Entry Terms：

1-(4-methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)- benzothiazolyl)ethanone hydrobromide

Computed Properties

Molecular Weight:286.4
XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:286.11398438
Monoisotopic Mass:286.11398438
Topological Polar Surface Area:69.5
Heavy Atom Count:20
Complexity:449
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Pifithrin-α

CAS No.: 63208-82-2

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