Z-VAD(OMe)-FMK
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Z-VAD(OMe)-FMK
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CAS No:
187389-52-2
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Formula:
C22H30FN3O7
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Chemical Name:
Z-VAD(OMe)-FMK
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Synonyms:
L-Alaninamide,N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-;N-[(Phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-alaninamide;3: PN: WO0158526 SEQID: 3 claimed sequence;Z-VAD(OMe)-FMK;13: PN: WO2005039629 PAGE: 18 claimed protein;3: PN: WO2011028611 SEQID: 3 unclaimed protein;Z-Val-Ala-Asp(OMe)-FMK;z-VAD-fmk;z-VAD-FMK;211292-24-9
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CAS No:
Characteristics
140
1.9
white powder
1.214±0.06 g/cm3 (20 ºC 760 Torr)
732.4±60.0 °C(Predicted)
396.7℃
DMSO: 20 mg/mL
−20°C
Z-VAD(OMe)-FMK Use and Manufacturing
Z-VAD(OMe)-FMK is a cell-permeable, competitive, and irreversible inhibitor of all caspases. Through this action, it inhibits cleavage of poly(ADP-ribose) polymerase, preventing apoptosis when used at 10-50 μM. It also blocks caspase-mediated apoptosis in vivo. Z-VAD(OMe)-FMK effectively prevents caspase action in inflammasomes.[Cayman Chemical]
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