 Home > Encyclopedia > Zibotentan

Zibotentan

Zibotentan structure

CAS No:
186497-07-4
Formula:
C19H16N6O4S
Chemical Name:
Zibotentan
Synonyms:
3-Pyridinesulfonamide,N-(3-methoxy-5-methyl-2-pyrazinyl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]-;3-Pyridinesulfonamide,N-(3-methoxy-5-methylpyrazinyl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]-;N-(3-Methoxy-5-methyl-2-pyrazinyl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]-3-pyridinesulfonamide;ZD 4054;Zibotentan;N-(3-Methoxy-5-methylpyrazin-2-yl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]pyridine-3sulfonamide
Categories:
Biochemical Engineering > Inhibitors

Description

Zibotentan (ZD4054) is an orally administered, potent and specific ETA-receptor (endothelin A receptor) antagonist (IC50 = 21 nM). IC50 value: 21 nM Target: ETA receptorZibotentan is capable of inhibiting or reducing the multitude of effects that are evoked by ET-1 activation of the ETA receptor and which promote tumor survival, growth and progression. Zibotentan (ZD4054) treatment produced significant inhibition of tumor growth in ovarian and breast xenografts.

Zibotentan Basic Attributes

Molecular Weight：

424.435

Exact Mass：

424.43

Characteristics

PSA：

141

XLogP3：

1.4

Density：

1.422

Boiling Point：

637.0±65.0 °C(Predicted)

Flash Point：

339.0±34.3 °C

Refractive Index：

1.628

Safety Information

Transport codes：

NONH for all modes of transport

RTECS Number：

UT7937700

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

Recommended Suppliers of Zibotentan

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Zibotentan (ZD4054)

CAS No.: 186497-07-4

Content: 99.00%

Inquiry