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PF03716556

PF03716556 structure

CAS No:
928774-43-0
Formula:
C22H26N4O3
Chemical Name:
PF03716556
Synonyms:
PF03716556;PF 3716556;8-[[(4R)-3,4-Dihydro-5-Methyl-2H-1-benzopyran-4-yl]aMino]-N-(2-hydroxyethyl)-N,2-diMethyliMidazo[1,2-a]pyridine-6-carboxaMide;N-(2-Hydroxyethyl)-N,2-diMethyl-8-{[(4R)-5-Methyl-3,4-dihydro-2H-chroMen-4-yl]aMino}iMidazo[1,2-a]pyridine-6-carboxa;PF3716556/PF-3716556/PF-03716556;(R)-N-(2-hydroxyethyl)-N,2-dimethyl-8-(5-methyl-3,4-dihydro-2H-chromen-4-ylamino)H-imidazo[1,2-a]pyridine-6-carboxamide;8-[[(4R)-3,4-Dihydro-5-methyl-2H-1-benzopyran-4-yl]amino]-N-(2-hydroxyethyl)-N,2-dimethylimidazo[1,2-a]pyridine-6-carboxamide PF 03716556;[N-(2-Hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide]
Categories:
Biochemical Engineering > Inhibitors

Description

PF 03716556 is a potent, and selective acid pump (H+,K+ ATPase) antagonist, with pIC50 value of 6.009.IC50 value:6.009 (pIC50)Target: H+,K+ ATPasePF-03716556 inhibited the activity of H+, K+-ATPase with pIC50 of 6.026 ± 0.112, 6.038 ± 0.039 and 6.009 ± 0.209 at pH 6.4 for porcine, canine and human ion-leaky membrane vesicles, respectively. PF-03716556 (PF03716556) is useful for treatment of gastroesophageal reflux disease.

PF03716556 Basic Attributes

Molecular Weight：

394.46684

Exact Mass：

394.200500

EC Number：

-0

UNII：

701L6668UD

DSSTox ID：

DTXSID10648811

Characteristics

PSA：

79.1

XLogP3：

2.9

Appearance：

white to tan

Density：

1.3±0.1 g/cm3

Melting Point：

143-145°C

Refractive Index：

1.651

Water Solubility：

DMSO: ≥10mg/mL

Storage Conditions：

Refrigerator

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

Drug Information

MeSH Entry Terms：

N-(2-hydroxyethyl)-N,2-dimethyl-8-((5-methyl-3,4-dihydro-2H-chromen-4-yl)amino)imidazo(1,2-a)pyridine-6-carboxamide

PF03716556 Use and Manufacturing

A novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease.

Computed Properties

Molecular Weight:394.5
XLogP3:2.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:394.20049070
Monoisotopic Mass:394.20049070
Topological Polar Surface Area:79.1
Heavy Atom Count:29
Complexity:576
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of PF03716556

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PF-3716556

CAS No.: 928774-43-0

Content: 99.00%

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