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TRAM-34

TRAM-34 structure

CAS No:
289905-88-0
Formula:
C22H17ClN2
Chemical Name:
TRAM-34
Synonyms:
Triarylmethane-34
Categories:
Biochemical Engineering > Inhibitors

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Description

TRAM-34 is a highly selective blocker of intermediate-conductance calcium-activated K+ channel (IKCa1) (Kd=20 nM).

TRAM-34 is an organochlorine compound.

TRAM-34 Basic Attributes

Molecular Weight：

344.843

Exact Mass：

344.108032

DSSTox ID：

DTXSID70349650

HScode：

2933199090

Characteristics

PSA：

17.82000

XLogP3：

5.65

Appearance：

off-white solid

Density：

1.1±0.1 g/cm3

Melting Point：

145-147°C

Boiling Point：

510.2±50.0 °C at 760 mmHg

Flash Point：

262.4±30.1 °C

Refractive Index：

1.617

Water Solubility：

soluble in DMSO at 2mg/ml. Insoluble in water

Storage Conditions：

2-8°C

Vapor Pressure：

5.04E-10mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

Marks：

Precautionary statement(s)：

P264, P270, P273, P301+P312, P330, P501

Hazard Statements：

H302-H413

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P273, P301+P312, P330, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole

TRAM-34 Use and Manufacturing

TRAM-34 blocks intermediate conductance calcium-activated potassium channel IKCa1 with a Kd of 20nM and exhibits exquisite selectivity for the channel.Clotrimazole impurity.

Computed Properties

Molecular Weight:344.8
XLogP3:5.6
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:4
Exact Mass:344.1080262
Monoisotopic Mass:344.1080262
Topological Polar Surface Area:17.8
Heavy Atom Count:25
Complexity:396
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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