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JAK3 Inhibitor

JAK3 Inhibitor structure

CAS No:
211555-04-3
Formula:
C16H14BrN3O3
Chemical Name:
JAK3 Inhibitor
Synonyms:
JAK3 Inhibitor;2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol;Phenol, 2-bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]-;4-(3'-Bromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline WHI-P 154;2-Bromo-4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol
Categories:
Biochemical Engineering > Inhibitors

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Description

WHI-P154 is a potent EGFR inhibitor, and also modestly blocks JAK3, with IC50s of 4 nM and 1.8 μM, respectively.

JAK3 Inhibitor Basic Attributes

Molecular Weight：

376.20466

Exact Mass：

375.021851

EC Number：

-0

UNII：

PG8BT6T9MB

DSSTox ID：

DTXSID60274407

Characteristics

PSA：

76.5

XLogP3：

3.7

Appearance：

white to brown

Density：

1.6±0.1 g/cm3

Flash Point：

238.2±28.7 °C

Refractive Index：

1.703

Water Solubility：

DMSO: soluble1mg/mL, clear (warmed)

Storage Conditions：

Store at RT

Safety Information

Transport codes：

UN 2811 6.1 / PGIII

wgk germany：

hazard class code：

22-36/37/38

safety instructions：

Marks：

Precautionary statement(s)：

P261-P301 + P310-P305 + P351 + P338

Hazard Statements：

H301-H315-H319-H335

Drug Information

MeSH Entry Terms：

4-(3'-bromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline

JAK3 Inhibitor Use and Manufacturing

WHI-P154 can act as antileukemic agent with apoptosis inducing activity.

Computed Properties

Molecular Weight:376.20
XLogP3:3.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:375.02185
Monoisotopic Mass:375.02185
Topological Polar Surface Area:76.5
Heavy Atom Count:23
Complexity:390
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes