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GO 6983

GO 6983 structure

CAS No:
133053-19-7
Formula:
C26H26N4O3
Chemical Name:
GO 6983
Synonyms:
gǒ 6983;GOE 6983;Gδ6983;1H-Pyrrole-2,5-dione, 3-[1-[3-(dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-;Go6983(96 %);3-[1-(3-Dimethylamino-propyl)-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-pyrrole-2,5-dione
Categories:
Biochemical Engineering > Inhibitors

Description

Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ, PKCδ and PKCζ with IC50 of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively.

3-[1-[3-(dimethylamino)propyl]-5-methoxy-3-indolyl]-4-(1H-indol-3-yl)pyrrole-2,5-dione is a member of indoles and a member of maleimides.

GO 6983 Basic Attributes

Molecular Weight：

442.516

Exact Mass：

442.200500

DSSTox ID：

DTXSID60274402

Characteristics

PSA：

79.4

XLogP3：

3.1

Appearance：

red

Density：

1.31±0.1 g/cm3(Predicted)

Boiling Point：

709.0±60.0 °C(Predicted)

Flash Point：

382.6±32.9 °C

Refractive Index：

1.670

Water Solubility：

DMSO: 20 mg/mL, clear, red

Storage Conditions：

−20°C

Vapor Pressure：

5.97E-20mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36

Marks：

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents that inhibit PROTEIN KINASES. (See all compounds classified as Protein Kinase Inhibitors.)

MeSH Entry Terms：

2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide

GO 6983 Use and Manufacturing

Broad spectrum protein kinase C (PKC) inhibitor (IC 50 values are 7, 7, 6, 10, 60 and 20000 nM for PKC α , PKC β , PKC γ , PKC δ , PKC ζ and PKC μ respectively). Displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury.

Computed Properties

Molecular Weight:442.5
XLogP3:3.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:442.20049070
Monoisotopic Mass:442.20049070
Topological Polar Surface Area:79.4
Heavy Atom Count:33
Complexity:796
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes