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FH 535

FH 535 structure

CAS No:
108409-83-2
Formula:
C13H10Cl2N2O4S
Chemical Name:
FH 535
Synonyms:
FH 535;N-(2-Methyl-4-nitrophenyl)-2,5-dichlorobenzenesulfonaMide;2,5-Dichloro-N-(2-Methyl-4-nitrophenyl)benzenesulfonaMide;2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide FH535;β-Catenin/Tcf Inhibitor, FH535;FH 535(FH-535)
Categories:
Biochemical Engineering > Inhibitors

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Description

Dark Yellow Solid

2,5-dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide is a sulfonamide.

FH 535 Basic Attributes

Molecular Weight：

361.2005

Exact Mass：

359.973846

DSSTox ID：

DTXSID60392716

HScode：

29350090

Characteristics

PSA：

100

XLogP3：

3.9

Density：

1.566±0.06 g/cm3(Predicted)

Melting Point：

141-142℃

Boiling Point：

526.3±60.0 °C(Predicted)

Flash Point：

272.1±32.9 °C

Refractive Index：

1.651

Water Solubility：

DMSO: soluble20mg/mL

Storage Conditions：

2-8°C

Safety Information

wgk germany：

hazard class code：

safety instructions：

Marks：

Precautionary statement(s)：

P264, P270, P280, P301+P312, P305+P351+P338, P310, P330, P501

Hazard Statements：

H302

GHS Classification：

|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P280, P301+P312, P305+P351+P338, P310, P330, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

FH535

FH 535 Use and Manufacturing

Antagonizes Wnt/β-catenin/Tcf-mediated transcription as well as PPARγ and δ activity. Able to inhibit the recruitment of the co-activators β-catenin and GRIP1, both of which are activators for both pathways.

Computed Properties

Molecular Weight:361.2
XLogP3:3.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:359.9738334
Monoisotopic Mass:359.9738334
Topological Polar Surface Area:100
Heavy Atom Count:22
Complexity:505
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes