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DBeQ

DBeQ structure

CAS No:
177355-84-9
Formula:
C22H20N4
Chemical Name:
DBeQ
Synonyms:
DBeQ;2,4-QuinazolinediaMine, N2,N4-bis(phenylMethyl)-;2,4-QuinazolinediaMine, N,N'-bis(phenylMethyl)-;JRF 12;N,N'-Dibenzylquinazoline-2,4-diamine;N2,N4-Dibenzylquinazoline-2,4-diamine;JRF;N,N'-Dibenzylquinazoline-2,4-diamine DBeQ
Categories:
Biochemical Engineering > Inhibitors

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DBeQ Basic Attributes

Molecular Weight：

340.421

Exact Mass：

340.169

DSSTox ID：

DTXSID3040936

Characteristics

PSA：

49.8

XLogP3：

5.3

Appearance：

white to beige

Boiling Point：

573.1±52.0°C at 760 mmHg

Water Solubility：

DMSO: ≥20mg/mL

Storage Conditions：

room temp

Safety Information

wgk germany：

hazard class code：

22-36

safety instructions：

Marks：

Precautionary statement(s)：

P264, P270, P280, P301+P312, P305+P351+P338, P330, P337+P313, P501

Hazard Statements：

H302

Drug Information

MeSH Entry Terms：

DBeQ cpd

DBeQ Use and Manufacturing

The ATPase p97 is an ubiquitin-selective chaperone known to play a critical role in the degradation of misfolded membrane and secretory proteins and has been linked to various cellular processes that require unfolding and disassembly of protein complexes. DBeQ is a selective, reversible, and ATP-competitive inhibitor of the ATPase p97 (Ki = 3.2 μM; IC50 = 1.5 μM). It does not exhibit activity when tested against a panel 170 protein kinases at concentrations as high as 15 μM. At 10 μM it blocks endoplasmic reticulum-associated degradation, impairing the autophagy pathway and promoting the activation of caspase-3 and -7 in cancer cells.[Cayman Chemical]

Computed Properties

Molecular Weight:340.4
XLogP3:5.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:340.16879665
Monoisotopic Mass:340.16879665
Topological Polar Surface Area:49.8
Heavy Atom Count:26
Complexity:403
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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