Vismodegib
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Vismodegib
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CAS No:
879085-55-9
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Formula:
C19H14Cl2N2O3S
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Chemical Name:
Vismodegib
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Synonyms:
Benzamide,2-chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)-;2-Chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)benzamide;GDC 0449;Vismodegib;Erivedge
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CAS No:
Description
Vismodegib (GDC-0449) is an orally active hedgehog pathway inhibitor with an IC50 of 3 nM. It also inhibits P-gp, ABCG2 with IC50 values of 3.0 μM and 1.4 μM, respectively.
Characteristics
84.5
3.8
1.4±0.1 g/cm3
561.6°C at 760 mmHg
293.4±30.1 °C
1.641
In water, solubility is pH dependent wtih 0.1 mg/mL at pH 7 and 0.99 mg/mL at pH 11
Store at room temperature 20 deg C to 25 deg C (68 deg F to 77 deg F); excursions permitted between 15 deg C to 30 deg C (59 deg F to 86 deg F)
7.6X10-14 mm Hg at 25 deg C (est)
Vismodegib Use and Manufacturing
Vismodegib (GDC-0449) is a potent, novel and specific hedgehog inhibitor with IC50 of 3 nM and also inhibits P-gp with IC50 of 3.0 μM.
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