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(-)-Triptonide

(-)-Triptonide structure

CAS No:
38647-11-9
Formula:
C20H22O6
Chemical Name:
(-)-Triptonide
Synonyms:
Trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1,6(3H,6aH)-dione,3b,4,4a,7a,7b,8b,9,10-octahydro-8b-methyl-6a-(1-methylethyl)-,(3bS,4aS,5aS,6aS,7aS,7bS,8aS,8bS)-;Triptolide,14-deoxy-14-oxo-;Trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan,triptolide deriv.;(3bS,4aS,5aS,6aS,7aS,7bS,8aS,8bS)-3b,4,4a,7a,7b,8b,9,10-Octahydro-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1,6(3H,6aH)-dione;Triptonide;Triptonid;(-)-Triptonide;Trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1,6(3H,6aH)-dione,3b,4,4a,7a,7b,8b,9,10-octahydro-8b-methyl-6a-(1-methylethyl)-,[3bS-(3bα,4aα,5aR*,6aβ,7aβ,7bα,8aR*,8bβ)]-;NSC 165677;PG 492
Categories:
Biochemical Engineering > Biosynthetic Natural Products

Description

Triptonide(NSC 165677; PG 492), extracted from Tripterygium wilfordii Hook, inhibited the proliferation of mouse splenocytes induced by suboptimal concentration of concanavalin A or lipopolysaccharide at concentrations of 0.02, 0.1, and 0.5 mg/ml.

Triptonide is a diterpene triepoxide that is triptobenzene K in which the acylhydroquinone moiety has undergone oxidation to the corresponding triepoxyketone derivative. It has been isolated from the roots of Tripterygium wilfordii. It has a role as an antineoplastic agent, an anti-inflammatory agent and an immunosuppressive agent. It is a cyclic ketone, an organic heteroheptacyclic compound, a diterpene triepoxide and a butenolide.

(-)-Triptonide Basic Attributes

Molecular Weight：

358.39

Exact Mass：

358.39

NSC Number：

165677

Characteristics

PSA：

XLogP3：

1.49

Appearance：

White crystalline powder

Density：

1.5±0.1 g/cm3

Melting Point：

224-225 °C @ Solvent: Hexane

Boiling Point：

581.1±50.0 °C at 760 mmHg

Flash Point：

257.8±30.2 °C

Refractive Index：

1.638

Safety Information

Transport codes：

UN 2811 6.1 / PGII

Precautionary statement(s)：

P201-P260-P284-P301 + P310 + P330-P304 + P340 + P310-P403 + P233

Hazard Statements：

H300 + H330-H361f

Drug Information

MeSH Entry Terms：

triptonide

Computed Properties

Molecular Weight:358.4
XLogP3:0.7
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:1
Exact Mass:358.14163842
Monoisotopic Mass:358.14163842
Topological Polar Surface Area:81
Heavy Atom Count:26
Complexity:860
Defined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 38647-11-9

Content: 99.00%

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CAS No.: 38647-11-9

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Guide of (-)-Triptonide

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Computed Properties
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(-)-Triptonide

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