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C′-Norvincaleukoblastine,4′-deoxy-20′,20′-difluoro-

C′-Norvincaleukoblastine,4′-deoxy-20′,20′-difluoro- structure

CAS No:
162652-95-1
Formula:
C45H54F2N4O8
Chemical Name:
C′-Norvincaleukoblastine,4′-deoxy-20′,20′-difluoro-
Synonyms:
Aspidospermidine-3-carboxylic acid,4-(acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-,methyl ester,(2β,3β,4β,5α,12R,19α)-;C′-Norvincaleukoblastine,4′-deoxy-20′,20′-difluoro-;4′-Deoxy-20′,20′-difluoro-5′-norvincaleukoblastine;20′,20′-Difluoro-3′,4′-dihydrovinorelbine;4′-Deoxy-20′,20′-difluoro-8′-norvincaleukoblastine;Vinflunine;Aspidospermidine-3-carboxylic acid,4-(acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-,methyl ester,(2β,3β,4β,5α,12β,19α)-
Categories:
Biochemical Engineering > Chinese Herbs

Description

ChEBI: An organic heteropentacyclic compound and an organic heterotetracyclic compound that is vinorelbine in which the tetrahydropyridine moiety of the heterotetracyclic part of the molecule has been redced to the corresponding piperidine, and in which the ethy group attached to this ring has been replaced by a 1,1-difluoroethyl group.Vinflunine (also referred to as PM391) is a semisynthetic analog of the natural vinca alkaloids vinblastine and vincristine that was approved by the Europea

C′-Norvincaleukoblastine,4′-deoxy-20′,20′-difluoro- Basic Attributes

Molecular Weight：

816.93

Exact Mass：

816.93

EC Number：

1806241-263-5

ATC Code：

L01CA05|L - Antineoplastic and immunomodulating agents

Characteristics

PSA：

133.87000

XLogP3：

5.01950

Density：

1.39±0.1 g/cm3(Predicted)

Refractive Index：

1.652

Drug Information

Drug Indication：

Javlor is indicated in monotherapy for the treatment of adult patients with advanced or metastatic transitional-cell carcinoma of the urothelial tract after failure of a prior platinum-containing regimen.Efficacy and safety of vinflunine have not been studied in patients with performance status ≥ 2.

MeSH Entry Terms：

Javlor

C′-Norvincaleukoblastine,4′-deoxy-20′,20′-difluoro- Use and Manufacturing

Use Classification：

Human drugs -> Javlor -> EMA Drug Category|Antineoplastic agents -> Human pharmacotherapeutic group

Computed Properties

Molecular Weight:816.9
XLogP3:4.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:10
Exact Mass:816.39097102
Monoisotopic Mass:816.39097102
Topological Polar Surface Area:134
Heavy Atom Count:59
Complexity:1720
Defined Atom Stereocenter Count:9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of C′-Norvincaleukoblastine,4′-deoxy-20′,20′-difluoro-

Description
Basic Attributes
Characteristics
Drug Information
Use and Manufacturing
Computed Properties
Learn More Other Chemicals

C′-Norvincaleukoblastine,4′-deoxy-20′,20′-difluoro-

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