Ginsenoside Rh2
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Ginsenoside Rh2
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CAS No:
78214-33-2
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Formula:
C36H62O8
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Chemical Name:
Ginsenoside Rh2
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Synonyms:
β-D-Glucopyranoside,(3β,12β)-12,20-dihydroxydammar-24-en-3-yl;Dammarane,β-D-glucopyranoside deriv.;(3β,12β)-12,20-Dihydroxydammar-24-en-3-yl β-D-glucopyranoside;Ginsenoside Rh2;3-O-β-D-Glucopyranosyl-20(S)-protopanaxadiol;20(S)-Ginsenoside Rh2;20(S)-Rh2;Ginsenoside 20-Rh2;Ginsenoside rh2(S);67400-18-4
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CAS No:
Description
Ginsenoside Rh2 is isolated from the root of Ginseng. Ginsenoside Rh2 induces the activation of caspase-8 and caspase-9. Ginsenoside Rh2 induces cancer cell apoptosis in a multi-path manner.
(20S)-ginsenoside Rh2 is a ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 3 has been converted to the corresponding beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position. It has a role as a plant metabolite, an antineoplastic agent, an apoptosis inducer, a cardioprotective agent, a bone density conservation agent and a hepatoprotective agent. It is a beta-D-glucoside, a 12beta-hydroxy steroid, a ginsenoside, a tetracyclic triterpenoid and a 20-hydroxy steroid. It derives from a hydride of a dammarane.
Characteristics
140
5.6
White powder
1.2±0.1 g/cm3
139-144 °C
726.4ºC at 760 mmHg
393.1±32.9 °C
1.572
2-8°C
Safety Information
NONH for all modes of transport
3
22
24/25
LZ5776539
Xn
P264, P270, P301+P312, P330, P501
H302
Ginsenoside Rh2 Use and Manufacturing
(20S)-Ginsenoside Rh2 is a triterpene saponin isolated from ginseng and has high anti-inflammatory and anti-cancer activities.
Computed Properties
Molecular Weight:622.9
XLogP3:5.6
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:7
Exact Mass:622.44446893
Monoisotopic Mass:622.44446893
Topological Polar Surface Area:140
Heavy Atom Count:44
Complexity:1070
Defined Atom Stereocenter Count:15
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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