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Ginsenoside Rf

Ginsenoside Rf structure

CAS No:
52286-58-5
Formula:
C42H72O14
Chemical Name:
Ginsenoside Rf
Synonyms:
β-D-Glucopyranoside,(3β,6α,12β)-3,12,20-trihydroxydammar-24-en-6-yl 2-O-β-D-glucopyranosyl-;Dammarane,β-D-glucopyranoside deriv.;(3β,6α,12β)-3,12,20-Trihydroxydammar-24-en-6-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside;Ginsenoside Rf;Panaxoside Rf;Rf ginsenoside;212055-75-9
Categories:
Biochemical Engineering > Plant Extracts

Description

Ginsenoside Rf is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca2+ channel.

Ginsenoside Rf is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy group at position 6 has been converted to the corresponding beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position. It has a role as a plant metabolite, an apoptosis inducer and an antineoplastic agent. It is a 12beta-hydroxy steroid, a 3beta-hydroxy steroid, a beta-D-glucoside, a disaccharide derivative, a ginsenoside, a tetracyclic triterpenoid, a 20-hydroxy steroid and a 3beta-hydroxy-4,4-dimethylsteroid. It derives from a hydride of a dammarane.

Ginsenoside Rf Basic Attributes

Molecular Weight：

801.01

Exact Mass：

801.01

UNII：

JOS8BON5YW

HScode：

29389090

Characteristics

PSA：

239

XLogP3：

2.7

Density：

1.3±0.1 g/cm3

Melting Point：

197～198℃

Flash Point：

505.5±34.3 °C

Refractive Index：

1.602

Storage Conditions：

-20°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

2-45-24/25

RTECS Number：

LY9536900

Marks：

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 41 companies from 2 notifications to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

ginsenoside Rf

Ginsenoside Rf Use and Manufacturing

Methods of Manufacturing

An activity assay of UGT109A1 was performed in a 100 muL reaction mixture containing 1 mMsubstrate (gensinosides Re, Rf, Rh1, or R1) dissolved in dimethyl sulfoxide (DMSO), 4 mM UDPG, 50mug purified UGT109A1, and 25 mM Tris-HCl buffer (pH 8.0). The reaction mixtures were incubatedat 37 C for 12 h and then terminated by adding 100 muL methanol. Subsequently, the reactants werecentrifuged at 10, 000× g for 20 min and filtered by a 0.22 mum filter prior to HPLC analysis.An activity assay of UGT109A1 was performed in a 100 muL reaction mixture containing 1 mMsubstrate (gensinosides Re, Rf, Rh1, or R1) dissolved in dimethyl sulfoxide (DMSO), 4 mM UDPG, 50mug purified UGT109A1, and 25 mM Tris-HCl buffer (pH 8.0). The reaction mixtures were incubatedat 37 C for 12 h and then terminated by adding 100 muL methanol. Subsequently, the reactants werecentrifuged at 10, 000× g for 20 min and filtered by a 0.22 mum filter prior to HPLC analysis.A solution of 20(S)-

Uses

Ginsenoside Rf is a new class of anti-tumor drugs isolated from ginseng, which is safe and efficient.

Computed Properties

Molecular Weight:801.0
XLogP3:2.7
Hydrogen Bond Donor Count:10
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:10
Exact Mass:800.49220697
Monoisotopic Mass:800.49220697
Topological Polar Surface Area:239
Heavy Atom Count:56
Complexity:1410
Defined Atom Stereocenter Count:21
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Learn More Other Chemicals

Ginsenoside Rh2

78214-33-2
Ginsenoside K

39262-14-1
Ginsenoside La

123617-34-5
Ginsenoside F1 Formula

53963-43-2
Ginsenoside Re Formula

52286-59-6
Ginsenoside Rh4 Formula

174721-08-5
Ginsenoside Rb1 Structure

41753-43-9
Ginsenoside Rb2 Structure

11021-13-9
What is Ginsenoside Rh1

63223-86-9
What is Ginsenoside Rd

52705-93-8

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Guide of Ginsenoside Rf

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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Ginsenoside Rf

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