Ginsenoside Rb1
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Ginsenoside Rb1
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CAS No:
41753-43-9
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Formula:
C54H92O23
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Chemical Name:
Ginsenoside Rb1
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Synonyms:
β-D-Glucopyranoside,(3β,12β)-20-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-;Dammarane,β-D-glucopyranoside deriv.;(3β,12β)-20-[(6-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside;Ginsenoside Rb1;Sanchinoside E1;Gypenoside III;Gynosaponin C;Arasaponin E1;Panaxoside Rb1;Sanchinoside Rb1;Notoginsenoside Rb1;NSC 310103;RB 1;12770-17-1;52286-61-0;87700-07-0;212055-66-8;393829-67-9;2412536-38-8;2416257-88-8
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CAS No:
Description
Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with an IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65 .
Characteristics
377
-2.20260
1.4±0.1 g/cm3
186-188 °C
1146°C at 760 mmHg
646.8±34.3 °C
1.626
methanol: soluble 9.80 - 10.20 mg/mL, clear, colorless to faintly yellow
2-8°C
oms-rat-ipr 50 mg/kg CPBTAL 24,2400,76
Safety Information
UN 1230 3/PG 2
3
20/21/22-39/23/24/25-23/24/25-11
26-36-45-36/37-16-7
LZ5856000
Xn,Xi,T,F
P261-P280-P301 + P312 + P330
H302 + H312 + H332
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|Aggregated GHS information provided by 44 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Ginsenoside Rb1 Use and Manufacturing
A major bioactive component of panax ginseng that promotes neurotransmitter release by modulating phosphorylation of synapsins through a cAMP-dependent protein kinase pathway. It has been reported to display immunostimulatory and anticancer effects.
Computed Properties
Molecular Weight:1109.3
XLogP3:0.3
Hydrogen Bond Donor Count:15
Hydrogen Bond Acceptor Count:23
Rotatable Bond Count:16
Exact Mass:1108.60293918
Monoisotopic Mass:1108.60293918
Topological Polar Surface Area:377
Heavy Atom Count:77
Complexity:2000
Defined Atom Stereocenter Count:28
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Reduce the body's oxygen consumption and improve the body's tolerance to hypoxia. Inhibit the aggregation of rabbit platelets caused by ADP. Dilate cerebral blood vessels and increase cerebral blood flow. Anti-thrombotic and anti-coagulation effects.
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Ginsenoside Rf
52286-58-5
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Ginsenoside Rb2
11021-13-9
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Ginsenoside Rh2
78214-33-2
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Ginsenoside La Formula
123617-34-5
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Ginsenoside Rh4 Formula
174721-08-5
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Ginsenoside Re Formula
52286-59-6
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Ginsenoside F1 Structure
53963-43-2
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Ginsenoside K Structure
39262-14-1
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What is Ginsenoside Rg2
52286-74-5
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52705-93-8