Ginsenoside Rg1
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Ginsenoside Rg1
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CAS No:
22427-39-0
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Formula:
C42H72O14
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Chemical Name:
Ginsenoside Rg1
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Synonyms:
β-D-Glucopyranoside,(3β,6α,12β)-3,12-dihydroxydammar-24-ene-6,20-diyl bis-;Ginsenoside Rg1;Panaxoside A;Dammarane,β-D-glucopyranoside deriv.;(3β,6α,12β)-3,12-Dihydroxydammar-24-ene-6,20-diyl bis-β-D-glucopyranoside;Sanchinoside C1;Ginsenoside A2;Panaxoside Rg1;Ginsenoside g1;Sanchinoside Rg1;Panaxsaponin Rg1;Rg1 ginsenoside;Rg1 ginsenoside;11054-31-2;50647-03-5;75139-45-6;252337-86-3;2416257-84-4
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CAS No:
Description
Ginsenoside Rg1 is one of the major active components of ginseng. Ginsenoside Rg1 displays promising effects by reducing cerebral Aβ levels. Ginsenoside Rg1 also reduces NF-κB nuclear translocation.
Ginsenoside Rg1 is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-glucopyranosides, and in which a double bond has been introduced at the 24-25 position. It has a role as a neuroprotective agent and a pro-angiogenic agent. It is a 12beta-hydroxy steroid, a beta-D-glucoside, a tetracyclic triterpenoid, a ginsenoside and a 3beta-hydroxy-4,4-dimethylsteroid. It derives from a hydride of a dammarane.|Ginsenosides are a class of steroid glycosides, and triterpene saponins, found exclusively in the plant genus Panax (ginseng). Ginsenosides have been the target of research, as they are viewed as the active compounds behind the claims of ginseng's efficacy. Because ginsenosides appear to affect multiple pathways, their effects are complex and difficult to isolate. Rg1 Appears to be most abundant in Panax ginseng (Chinese/Korean Ginseng). It improves spatial learning and increase hippocampal synaptophysin level in mice, plus demonstrates estrogen-like activity.
Characteristics
239.22000
2.7
White Crystalline Powder
1.33 g/cm3
191-194 °C
898.5ºC at 760 mmHg
497.2ºC
1.601
0mmHg at 25°C
Safety Information
UN 1230 3/PG 2
3
R22
S2; S45
LY9537200
Xn
P301 + P312 + P330
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 42 companies from 2 notifications to the ECHA C&L Inventory.
Drug Information
A class of drugs producing both physiological and psychological effects through a variety of mechanisms. They can be divided into "specific" agents, e.g., affecting an identifiable molecular mechanism unique to target cells bearing receptors for that agent, and "nonspecific" agents, those producing effects on different target cells and acting by diverse molecular mechanisms. Those with nonspecific mechanisms are generally further classed according to whether they produce behavioral depression or stimulation. Those with specific mechanisms are classed by locus of action or specific therapeutic use. (From Gilman AG, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p252) (See all compounds classified as Central Nervous System Agents.)
M1 (20- O -β- D -glucopyranosyl-20( S )- protopanaxadiol ) is a ppd-type monoglucoside ginsenoside metabolized by intestinal bacteria in humans
ginsenoside Rg1
Ginsenoside Rg1 Use and Manufacturing
Ginsenoside Rg1 protects against arthitis through osteoclast differentiation inhibition. Anti-tumor agent, inhibits the NF-kB-dependant MMP-expression in PMA (phorbol myristate acetate)-induced tumor cell invasion.
Computed Properties
Molecular Weight:801.0
XLogP3:2.7
Hydrogen Bond Donor Count:10
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:10
Exact Mass:800.49220697
Monoisotopic Mass:800.49220697
Topological Polar Surface Area:239
Heavy Atom Count:56
Complexity:1410
Defined Atom Stereocenter Count:21
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Reduce the body's oxygen consumption and improve the body's tolerance to hypoxia. Inhibit the aggregation of rabbit platelets caused by ADP. Dilate cerebral blood vessels and increase cerebral blood flow. Anti-thrombotic and anti-coagulation effects.
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Learn More Other Chemicals
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Ginsenoside Rh2
78214-33-2
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Ginsenoside K
39262-14-1
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Ginsenoside La
123617-34-5
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Ginsenoside Re Formula
52286-59-6
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Ginsenoside Rf Formula
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Ginsenoside Rh4 Structure
174721-08-5
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Ginsenoside Rb2 Structure
11021-13-9
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What is Ginsenoside Rb1
41753-43-9
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What is Ginsenoside Rh1
63223-86-9