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Chelerythrine

Chelerythrine structure

CAS No:
34316-15-9
Formula:
C21H18NO4
Chemical Name:
Chelerythrine
Synonyms:
[1,3]Benzodioxolo[5,6-c]phenanthridinium,1,2-dimethoxy-12-methyl-;Chelerythrine;1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium;Cheleritrine;Toddalin;Toddaline;Broussonpapyrine;2870-15-7;11046-21-2
Categories:
Biochemical Engineering > Biosynthetic Natural Products

Description

Chelerythrine is a natural alkaloid, acts as a potent and selective Ca2+/phospholopid-dependent PKC antagonist, with an IC50 of 0.7 μM[1]. Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity[2].

Chelerythrine is a benzophenanthridine alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae. It has a role as an EC 2.7.11.13 (protein kinase C) inhibitor, an antibacterial agent and an antineoplastic agent. It is a benzophenanthridine alkaloid and an organic cation.

Chelerythrine Basic Attributes

Molecular Weight：

348.37192

Exact Mass：

348.123047

EC Number：

251-930-0

UNII：

E3B045W6X0

HScode：

2933990090

Characteristics

PSA：

40.80000

XLogP3：

0.72060

Density：

1.2985 (rough estimate)

Melting Point：

199 °C @ Solvent: Ethyl acetate

Storage Conditions：

Desiccate at -20°C

Safety Information

hazard class code：

20/21/22

safety instructions：

36/37

Marks：

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P310, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H300

GHS Classification：

|Danger|H300 (50%): Fatal if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)|Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)

MeSH Entry Terms：

chelerythrine

Computed Properties

Molecular Weight:348.4
XLogP3:4.6
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:348.12358306
Monoisotopic Mass:348.12358306
Topological Polar Surface Area:40.8
Heavy Atom Count:26
Formal Charge:1
Complexity:516
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of Chelerythrine

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Computed Properties
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Chelerythrine

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