CUCURBIT(8)URIL

Cucurbit[8]uril is a cucurbituril.

Synthesis of cucurbit[n]urils in methanesulphonic acid using Diethoxymethane(Ethylal)Unsubstituted glycoluril (19.94 g) and methane sulphonic acid (neat, 82 mL) were placed in a reaction flask and heated to 80 °C. Ethylal (35.21 mL) was added in drop-wise and the reaction mixture was then heated to 100 °C (internal temp) for 18 hours. The reaction mixture was cooled and added to acetone (410 ml) to produce a brown powder which was analysed bySynthesis of cucurbit[n]urils in hydrochloric acid using paraformaldehyde Unsubstituted glycoluril (20 g) and hydrochloric acid (37 percent w/v, 30 mL) were placed in a reaction flask and heated to 90°C. Paraformaldehyde (8.87 g) was added in portion-wise and the reaction mixture was then heated to 100 °C (internal) for 18 hours. The reaction mixture was cooled and added to methanol (150 mL) to produce a beige powder which was analysed bySynthesis of cucurbit[n]urils in methanesulphonic acid usingTetramethoxymethylglycoluril (TMMG)Unsubstituted glycoluril (19.94 g) and methane sulphonic acid (neat, 82 ml_) were placed in a reaction flask and heated to 80 °C. TMMG (44.66 g) was added in drop-wise and the reaction mixture was then heated to 100 °C (internal temp) for 18 hours. The reaction mixture was cooled and added to methanol (410 ml) to produce a beige powder which was analysed by

Molecular Weight:1329.1
XLogP3:-9.1
Hydrogen Bond Acceptor Count:16
Exact Mass:1328.39260358
Monoisotopic Mass:1328.39260358
Topological Polar Surface Area:377
Heavy Atom Count:96
Complexity:2960
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes