N-(2-Methyl-4-chlorophenyl)-N′,N′-dimethylthiourea

Chloromethiuron is a member of thioureas.

Preparation method Preparation of a pair of chloro-o-toluidine hydrochloride. After mixing 0.25 mol of o-toluidine with 125 mL of nitrobenzene, add acetic anhydride dropwise, react for 2 hours, cool and ventilate chlorine, stop the chlorination after a large amount of white solid appears . Add 10.5mL concentrated hydrochloric acid and 28mL water, gradually heat, stir and react for 4h, dissolve the solid, cool and filter with suction, wash with a little nitrobenzene, and dry to obtain 36.8g of p-chloro-o-toluidine salt with a yield of 82.1%. Synthesis of diflubenzuron After mixing 0.1 mol p-chloro-o-toluidine hydrochloride, 56 mL nitrobenzene, 4.5 g sodium hydroxide and 16 mL, heating to 80-85°C, the solid is dissolved. Cool, add 0.2mol carbon disulfide dropwise at room temperature, then cool to 1℃, dropwise add 24mL 33% dimethylamine aqueous solution, the reaction exotherms, the solid dissolves, reflux reaction for 5h, cooling, suction filtration, filter cake washing with nitrobenzene, After washing with water and drying, 18.9 g of yellow solid was obtained, and the yield was 81.8%. Pure product can be obtained after recrystallization.

It is a substitute for urea pesticides. Used to dip cattle, sheep, horses, and dogs, to prevent and control various ticks, but also to prevent ticks that are resistant to other acaricides.

Molecular Weight:228.74
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:228.0487973
Monoisotopic Mass:228.0487973
Topological Polar Surface Area:47.4
Heavy Atom Count:14
Complexity:208
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes