Prothiofos

ChEBI: An organic thiophosphate that is the 2,4-dichlorophenyl ester of O-ethyl S-propyl dithiophosphoric acid.

Prothiofos is an organic thiophosphate that is the 2,4-dichlorophenyl ester of O-ethyl S-propyl dithiophosphoric acid. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, an EC 3.1.1.8 (cholinesterase) inhibitor, an agrochemical and an insecticide. It is an organic thiophosphate, a dichlorobenzene and an organosulfur compound. It derives from a 2,4-dichlorophenol.

PrSP(O)Cl2 and powdered P2S5 are heated at 130°C for 3h to obtain PrSP(S)Cl2. It is dissolved in benzene and treated with ethanol and triethylamine at 0～5℃ to obtain -167℃PrS(EtO)O(S)Cl. Then react with 2, 4-dichlorophenol and carbon potassium carbonate in methyl ethyl ketone and reflux for 3 hours to obtain prothion. The reaction can also be carried out in a reactor equipped with a stirrer, thermometer and reflux condenser. Phosphorus pentasulfide, 2, 4-dichlorophenol, catalyst and organic solvent are reacted at a lower temperature for 2 to 3 hours, and then the acid is added. After the reaction is completed, the reaction is completed, cooled and filtered, washed with water to neutrality, and dissolved under reduced pressure to obtain profenofos.

Asymmetric organophosphorus pesticides, with a broad spectrum of biological activity, no systemic. It is highly effective against Lepidoptera larvae, especially against aphids, thrips, mealybugs, leaf curls and worms that produce cross resistance against carbamates and other organophosphorus insecticides. The housefly of this strain has good killing activity, is equally effective against mosquitoes and larvae, is effective against coleopteran pests, and is weak against pests of the leafhopper family, the assididae family and the ladybird family. It has obvious activity on the larval stage of underground pests, and is also promising for controlling important underground pests such as golden needleworms, ground tigers and termites. The emulsifiable concentrate is usually sprayed 1000 times with water, the vegetable safety interval is 21d, and the citrus is 45d.

Molecular Weight:345.2
XLogP3:4.9
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:343.9628144
Monoisotopic Mass:343.9628144
Topological Polar Surface Area:75.8
Heavy Atom Count:18
Complexity:294
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes