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Methoxyacetyl chloride

Methoxyacetyl chloride structure

CAS No:
38870-89-2
Formula:
C3H5ClO2
Chemical Name:
Methoxyacetyl chloride
Synonyms:
Acetyl chloride,2-methoxy-;Acetyl chloride,methoxy-;2-Methoxyacetyl chloride;Methoxyacetyl chloride;α-Methoxyacetyl chloride;Methoxyacetic acid chloride;NSC 82321
Categories:
Chemical Reagents > Organic Reagents

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Description

clear colorless to yellow liquid

Methoxyacetyl chloride Basic Attributes

Molecular Weight：

108.52

Exact Mass：

108.52

BRN：

1740244

EC Number：

254-169-2

UNII：

T66S02B1S3

NSC Number：

82321

DSSTox ID：

DTXSID5075238

HScode：

29189900

Characteristics

PSA：

26.3

XLogP3：

0.30

Appearance：

Clear colorless to yellow Liquid

Density：

1.2±0.1 g/cm3

Melting Point：

Boiling Point：

112.5 °C

Flash Point：

84 °F

Refractive Index：

1.401

Water Solubility：

Solubility in water: reaction.Miscible with acetone, ether, carbon tetrachloride and chloroform.

Storage Conditions：

2-8°C

Safety Information

Packing level：

Hazard category：

Transport codes：

UN 2920 8/PG 2

wgk germany：

hazard class code：

10-34-36/37

safety instructions：

26-36/37/39-45-25-16

Marks：

Precautionary statement(s)：

P261-P280-P305 + P351 + P338-P310

Hazard Statements：

H226-H314-H335

GHS Classification：

|Danger|H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P260, P261, P264, P271, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P311, P312, P321, P363, P370+P378, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 54 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Methoxyacetyl chloride Use and Manufacturing

Methods of Manufacturing

The preparation method is to put methanol and flake NaOH into the reaction flask, reflux and react for 30min, then add a certain amount of chloroacetic acid, cool and add a certain amount of chloroacetic acid, heat up the reaction for 2h, after reflux, evaporate the methanol, then azeotropic dehydration, after the water is gone , Then cool to below 10°C, add toluene and SOCl2 as acylating agent, react at 45°C for 1h, cool to 20°C, after post-treatment, distillation to obtain the product. CH3ONa+ClCH2COOH→CH3OCH2COONaCH3OCH2COONa+SOCl2→ CH3OCH2COCl+NaCl+SO2↑

Uses

Used as medicine and dye intermediate

Computed Properties

Molecular Weight:108.52
XLogP3:0.7
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:107.9978071
Monoisotopic Mass:107.9978071
Topological Polar Surface Area:26.3
Heavy Atom Count:6
Complexity:52.8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Methoxyacetic acid

Dimethylformamide

Thionyl chloride

Chloroacetic acid

Benzoyl chloride

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