4-tert-Butylbenzohydrazide

white to light beige crystalline powder or

DryPowder

Preparation of starting material :4 -tert-Butylbenzhydrazine (YZ -1-203):To methyl 4 -tert-butylbenzoate (40.0 g, 0.21mol) in dioxane (120 ml) was added hydrazine hydrate (60.0 g, 1.20mol). The reaction mixture was refluxed for 28 hours. The reaction mixture was cooled down to room temperature and poured into water (1000.0 ml). The white pr oduct solid was collected by filtration and dried under vacuum. The yield of the reaction was 36.0 g (90.0 percent).To a 150 ml round bottom flask was added tert-butylbenzoic acid (1.78 g; 10 mmol), 40 ml of methanol, 1 ml of concentrated sulfuric acid, After the reaction was over night, the excess solvent was removed by a rotary evaporator, and the remaining oily liquid was dissolved in chloroform, 10ml hydrazine hydrate, room temperature reaction after 48h out, filtration, solid 1.6g (80percent).A solution of methyl 4-tert-butylbenzoate (5.15 g, 26.8 mmol) and hydrazine monohydrate (1.50 ml, 30.0 mmol) in MeOH (15 mL) was stirred for 2 d. After removal of the solvent in vacuo, the residuewas recrystallized from MeOH to give 4-tert-butylbenzohydrazide (2.94 g, 15.3 mmol, 57percent) as acolorless crystal.Synthesis Example 4

Intermediates

< 25,000 lb

Molecular Weight:192.26
XLogP3:2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:192.126263138
Monoisotopic Mass:192.126263138
Topological Polar Surface Area:55.1
Heavy Atom Count:14
Complexity:200
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes