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(+)-Flunoxaprofen

(+)-Flunoxaprofen structure

CAS No:
66934-18-7
Formula:
C16H12FNO3
Chemical Name:
(+)-Flunoxaprofen
Synonyms:
5-Benzoxazoleacetic acid,2-(4-fluorophenyl)-α-methyl-,(αS)-;5-Benzoxazoleacetic acid,2-(4-fluorophenyl)-α-methyl-,(S)-;(αS)-2-(4-Fluorophenyl)-α-methyl-5-benzoxazoleacetic acid;Flunoxaprofen;Priaxim;(S)-(+)-Flunoxaprofen;(+)-Flunoxaprofen;(S)-Flunoxaprofen;RV 12424;(S)-(+)-2-(p-Fluorophenyl)-α-methyl-5-benzoxazoleethanoic acid
Categories:
Active Pharmaceutical Ingredients > Antipyretic Analgesics

Description

ChEBI: A monocarboxylic acid that is propionic acid substituted at position 2 by a 2-(4-chlorophenyl)-1,3-benzoxazol-5-yl group (the S-enantiomer). Although it was shown to be effective in treatment of rheumatoid arthritis and osteoarthritis, the clinical use of flunoxaprofen was discontinued due to possible hepatotoxic side-effects.

(+)-Flunoxaprofen Basic Attributes

Molecular Weight：

285.273

Exact Mass：

285.27

Characteristics

PSA：

63.3

XLogP3：

3.82200

Density：

1.334g/cm3

Melting Point：

162-164 °C

Boiling Point：

419.4ºC at 760 mmHg

Flash Point：

207.5ºC

Refractive Index：

1.617

Toxicity：

LD50 orally in mice: ~1200 mg/kg (Dunwell)

Specific rotation：

D20 +50° (c = 2% in DMF)