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Alminoprofen

Alminoprofen structure

CAS No:
39718-89-3
Formula:
C13H17NO2
Chemical Name:
Alminoprofen
Synonyms:
Benzeneacetic acid,α-methyl-4-[(2-methyl-2-propen-1-yl)amino]-;Benzeneacetic acid,α-methyl-4-[(2-methyl-2-propenyl)amino]-;α-Methyl-4-[(2-methyl-2-propen-1-yl)amino]benzeneacetic acid;Alminoprofen;EB 382;(±)-Alminoprofen;Minalfene;2-(4-((2-Methylallyl)amino)phenyl)propanoic acid;2-[4-[(2-Methylprop-2-en-1-yl)amino]phenyl]propanoic acid;54362-70-8
Categories:
Active Pharmaceutical Ingredients > Antipyretic Analgesics

Description

ChEBI: A substituted aniline that is ibuprofen in which the isobutyl group is replaced by a (2-methylprop-2-en-1-yl)amino group. A non-steroidal anti-inflammatory drug, it is used for treatment of inflammatory and rheumatic disorders.

Alminoprofen is a substituted aniline that is ibuprofen in which the isobutyl group is replaced by a (2-methylprop-2-en-1-yl)amino group. A non-steroidal anti-inflammatory drug, it is used for treatment of inflammatory and rheumatic disorders. It has a role as a non-steroidal anti-inflammatory drug, an antirheumatic drug, an antipyretic, an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor, an EC 3.1.1.4 (phospholipase A2) inhibitor, a cyclooxygenase 2 inhibitor and a non-narcotic analgesic. It is a monocarboxylic acid, a substituted aniline, an amino acid and a secondary amino compound.|Alminoprofen is a non-steroidal anti-inflammatory drug (NSAID) whose physiochemical characteristics make it a member of the phenylpropionic acid class of chemical substances.

Alminoprofen Basic Attributes

Molecular Weight：

219.282

Exact Mass：

219.28

EC Number：

254-604-6

ATC Code：

M - Musculo-skeletal system

Characteristics

PSA：

49.3

XLogP3：

2.93570

Density：

1.107g/cm3

Melting Point：

107 °C

Boiling Point：

373.1ºC at 760 mmHg

Flash Point：

179.4ºC

Refractive Index：

1.571

Toxicity：

LD50 orally in mice: 2400 mg/kg (Dumaitre)

Drug Information

MeSH：

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

MeSH Entry Terms：

2-(4-((2-methyl-2-propenyl)amino)phenyl)propionic acid

Alminoprofen Use and Manufacturing

Alminoprofen is a nonsteroidal antiinflammatory drugs (NSAID) of the phenylpropionic acid class. Alminoprofen maybe a useful therapeutic option in the management of immune dysfunction in rheumatoid arthritis.

Computed Properties

Molecular Weight:219.28
XLogP3:3.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:219.125928785
Monoisotopic Mass:219.125928785
Topological Polar Surface Area:49.3
Heavy Atom Count:16
Complexity:255
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes