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Pirprofen

Pirprofen structure

CAS No:
31793-07-4
Formula:
C13H14ClNO2
Chemical Name:
Pirprofen
Synonyms:
Benzeneacetic acid,3-chloro-4-(2,5-dihydro-1H-pyrrol-1-yl)-α-methyl-;Hydratropic acid,3-chloro-4-(3-pyrrolin-1-yl)-;3-Chloro-4-(2,5-dihydro-1H-pyrrol-1-yl)-α-methylbenzeneacetic acid;2-[3-Chloro-4-(3-pyrrolin-1-yl)phenyl]propionic acid;Su 21524;Pirprofen;Rengasil;(±)-Pirprofen;Racemic pirprofen;Seflenyl;Rangasil 400;2-[3-Chloro-4-(2,5-dihydropyrrol-1-yl)-phenyl]propanoic acid;3-Chloro-4-(3-pyrrolin-1-yl)hydratropic acid;2-[3-Chloro-4-(2,5-dihydro-1H-pyrrol-1-yl)phenyl]propanoic acid;46801-03-0
Categories:
Active Pharmaceutical Ingredients > Antipyretic Analgesics

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Description

Pirprofen is a pyrroline.

Pirprofen Basic Attributes

Molecular Weight：

251.712

Exact Mass：

251.71

EC Number：

250-805-8

DSSTox ID：

DTXSID7023489

ATC Code：

M - Musculo-skeletal system

HScode：

2933990090

Characteristics

PSA：

40.5

XLogP3：

2.96930

Density：

1.298g/cm3

Melting Point：

99 °C

Boiling Point：

410.8ºC at 760mmHg

Flash Point：

202.2ºC

Refractive Index：

1.604

Drug Information

MeSH：

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

MeSH Entry Terms：

2-(3-chloro-4-(3-pyrroli-1-yl)phenyl)propionic acid

Pirprofen Use and Manufacturing

Uses

Anti-inflammatory.

Use Classification：

Pharmaceuticals

Computed Properties

Molecular Weight:251.71
XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:251.0713064
Monoisotopic Mass:251.0713064
Topological Polar Surface Area:40.5
Heavy Atom Count:17
Complexity:311
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes