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Butibufen

Butibufen structure

CAS No:
55837-18-8
Formula:
C14H20O2
Chemical Name:
Butibufen
Synonyms:
Benzeneacetic acid,α-ethyl-4-(2-methylpropyl)-;α-Ethyl-4-(2-methylpropyl)benzeneacetic acid;Butibufen;2-(4-Isobutylphenyl)butyric acid;DF 1903Y;2-[4-(2-Methylpropyl)phenyl]butanoic acid
Categories:
Active Pharmaceutical Ingredients > Antipyretic Analgesics

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Description

White to Off-White Solid

Butibufen is a monoterpenoid.

Butibufen Basic Attributes

Molecular Weight：

220.3074

Exact Mass：

220.31

EC Number：

259-849-2

Characteristics

PSA：

37.3

XLogP3：

3.46330

Density：

1.015g/cm3

Melting Point：

52 °C

Boiling Point：

335.1ºC at 760mmHg

Flash Point：

232.1ºC

Refractive Index：

1.515

Toxicity：

LD50 orally in mice: 810 mg/kg (Carretero)

Drug Information

MeSH：

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

MeSH Entry Terms：

butibufen

Butibufen Use and Manufacturing

Anti-inflammatory.

Computed Properties

Molecular Weight:220.31
XLogP3:3.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:220.146329876
Monoisotopic Mass:220.146329876
Topological Polar Surface Area:37.3
Heavy Atom Count:16
Complexity:215
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Sulfuric acid