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Fenbufen

Fenbufen structure

CAS No:
36330-85-5
Formula:
C16H14O3
Chemical Name:
Fenbufen
Synonyms:
[1,1′-Biphenyl]-4-butanoic acid,γ-oxo-;Propionic acid,3-(4-biphenylylcarbonyl)-;γ-Oxo[1,1′-biphenyl]-4-butanoic acid;3-(4-Biphenylcarbonyl)propionic acid;Fenbufen;CL 82204;Cinopal;Bufemid;Napanol;3-(4-Phenylbenzoyl)propionic acid;4-(4-Phenylphenyl)-4-oxobutyric acid;Lederfen;Cinopol;4-(Biphenyl-4-yl)-4-oxobutanoic acid;3-[(Biphenyl-4-yl)carbonyl]propionic acid;4-(1,1′-Biphenyl-4-yl)-4-oxobutanoic acid
Categories:
Active Pharmaceutical Ingredients > Antipyretic Analgesics

Description

Fenbufen is a non-steroidal anti-inflammatory drug in the propionic acid derivatives class.

Fenbufen is a member of biphenyls and a 4-oxo monocarboxylic acid. It has a role as a non-steroidal anti-inflammatory drug.|Fenbufen is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It can also be used to relieve backaches, sprains, and fractures. Fenbufen is available as a capsule or tablet sold with the brand names Cepal, Cinopal, Cybufen, Lederfen, and Reugast. Fenbufen acts by preventing cyclooxygenase from producing prostaglandins which can cause inflammation.

Fenbufen Basic Attributes

Molecular Weight：

254.28

Exact Mass：

254.28

EC Number：

252-979-0

UNII：

9815R1WR9B

NSC Number：

757812

DSSTox ID：

DTXSID9023043

ATC Code：

M - Musculo-skeletal system

HScode：

2918300090

Characteristics

PSA：

54.4

XLogP3：

3.2

Appearance：

White Solid

Density：

1.2±0.1 g/cm3

Melting Point：

186 °C

Boiling Point：

470.2°C at 760 mmHg

Flash Point：

252.3±20.5 °C

Refractive Index：

1.585

Water Solubility：

Very slightly soluble in water, slightly soluble in acetone, in ethanol (96 per cent) and in methylene chloride.

Storage Conditions：

Refrigerator

Toxicity：

Oral-rat LD50: 200 mg/kg; Oral-Mouse LD50: 795 mg/kg

Flammability characteristics：

Burning produces irritating smoke; side effects of the drug: cough; sweating; changes in body temperature

Safety Information

Packing level：

III

Hazard category：

6.1

Transport codes：

UN 2811 6.1/PG 3

wgk germany：

hazard class code：

safety instructions：

28-45

RTECS Number：

DV1761000

Marks：

Storage features：

Treasury is ventilated, low temperature and dry; stored separately from food materials

Precautionary statement(s)：

P301 + P310

Hazard Statements：

H301

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 40 companies from 2 notifications to the ECHA C&L Inventory.

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH：

Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes. (See all compounds classified as Cyclooxygenase Inhibitors.)|Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

MeSH Entry Terms：

Cinopal

Fenbufen Use and Manufacturing

Methods of Manufacturing

In the presence of anhydrous aluminum trichloride, biphenyl and succinic anhydride were condensed in nitrobenzene to produce fenbufen with a yield of 70%.

Uses

muscle relaxant (smooth)

Use Classification：

Pharmaceuticals

Computed Properties

Molecular Weight:254.28
XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:254.094294304
Monoisotopic Mass:254.094294304
Topological Polar Surface Area:54.4
Heavy Atom Count:19
Complexity:310
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product is a long-acting non-steroidal anti-inflammatory drug. It can inhibit the activity of cyclooxygenase and reduce the synthesis of prostaglandins. Animal experiments show that the anti-inflammatory and analgesic effects of this product are weaker than indomethacin, but stronger than aspirin.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Fenbufen Tablets
Ingredients	The main ingredient of this product is fenbufen (C16H14O3), whose chemical name is 3-(4-biphenylcarbonyl) propionic acid. Its structural formula is: Molecular formula: C16H14O3 Molecular weight: 254.28
Indication	There may be cross-allergic reactions with other nonsteroidal anti-inflammatory drugs.
Specifications	0.15g
Manufacturer	Livzon Pharmaceutical Grouping Limin Pharmaceutical FACTORY

Fenbufen
Manufacturer	Shandong XinYi Pharmaceutical Co., Ltd.

Fenbufen Capsules
Ingredients	The main ingredient of this product is fenbufen. Its chemical name is 3-(4-biphenylcarbonyl) propionic acid. Molecular formula: C16H14O3 Molecular weight: 254.28
Indication	Not yet clear.
Specifications	0.15g
Manufacturer	Shanghai Modern Hasen (Shangqiu) Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Kaifeng Pharmaceutical (GROUP) Co., Ltd.

China
Active
Shandong XinYi Pharmaceutical Co., Ltd.

China
Active
Liaoyuan City Baikang Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

Recommended Suppliers of Fenbufen

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

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Fenbufen

CAS No.: 36330-85-5

Content: 99.00%

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