 Home > Encyclopedia > (±)-Pranoprofen

(±)-Pranoprofen

(±)-Pranoprofen structure

CAS No:
52549-17-4
Formula:
C15H13NO3
Chemical Name:
(±)-Pranoprofen
Synonyms:
5H-[1]Benzopyrano[2,3-b]pyridine-7-acetic acid,α-methyl-;α-Methyl-5H-[1]benzopyrano[2,3-b]pyridine-7-acetic acid;Y 8004;2-(5H-[1]-Benzopyrano[2,3-b]pyridin-7-yl)propionic acid;Pranoprofen;Niflan;α-Methyl-5H-[1]benzopyrano[2,3-b]pyridine-7-ylacetic acid;(±)-Pranoprofen;(RS)-Pranoprofen;dl-Pranoprofen;Oftalar;2-(5H-Chromeno[2,3-b]pyridin-7-yl)propanoic acid;103813-86-1
Categories:
Active Pharmaceutical Ingredients > Antipyretic Analgesics

Description

Pranoprofen is a non-steroidal anti-inflammatory drug used in ophthalmology. Target: PGE2Pranoprofen 0.1% was found to be as effective as diclofenac sodium 0.1% in reducing inflammation and pain after strabismus surgery. Pranoprofen could be used as a safe and effective anti-inflammatory alternative for the treatment of inflammation following strabismus surgery [1]. pranoprofen has efficacy equivalent to a moderate-potency corticosteroid with a better safety profile. It should be conside

Pranoprofen is a pyridochromene.

(±)-Pranoprofen Basic Attributes

Molecular Weight：

255.27

Exact Mass：

255.27

EC Number：

1308068-626-2

NSC Number：

759832

DSSTox ID：

DTXSID1023497

ATC Code：

S01BC09|S - Sensory organs

HScode：

2934999090

Characteristics

PSA：

59.4

XLogP3：

2.7

Density：

1.3±0.1 g/cm3

Melting Point：

182-183 °C

Boiling Point：

465.7°C at 760 mmHg

Flash Point：

235.5±25.4 °C

Refractive Index：

1.628

Toxicity：

LD50 in male mice, rats (mg/kg): 447.3, 87.3 orally (Edanaga)

Safety Information

Transport codes：

UN 2811 6.1 / PGIII

RTECS Number：

DJ3100950

Precautionary statement(s)：

P301 + P310 + P330

Hazard Statements：

H301

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

Agents that increase uric acid excretion by the kidney (URICOSURIC AGENTS), decrease uric acid production (antihyperuricemics), or alleviate the pain and inflammation of acute attacks of gout. (See all compounds classified as Gout Suppressants.)|Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

MeSH Entry Terms：

2-(5H-(1)benzopyrano(2,3-b)pyridin-7-yl)propionic acid

(±)-Pranoprofen Use and Manufacturing

Anti-inflammatory used in ophthalmology.

Computed Properties

Molecular Weight:255.27
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:255.08954328
Monoisotopic Mass:255.08954328
Topological Polar Surface Area:59.4
Heavy Atom Count:19
Complexity:346
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Pranoprofen
Specifications	－－－－
Manufacturer	Guangzhou Hanpu Pharmaceutical Co., Ltd.

Pranoprofen eye drops
Ingredients	Pranoprofen, in addition to pranoprofen, also contains additives such as boric acid, borax, polysorbate 80, sodium edetate, benzalkonium chloride, etc. Pranoprofen is a propionic acid compound with a tricyclic structure. Chemical name: 2-(5H-[1]benzopyrano[2,3-b]pyridin-7-yl)propionic acid Molecular formula: C15H13NO3
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	5ml: 5mg

Pranoprofen eye drops
Ingredients	Pranoprofen, in addition to pranoprofen, also contains additives such as boric acid, borax, polysorbate 80, sodium edetate, benzalkonium chloride, etc. Pranoprofen is a propionic acid compound with a tricyclic structure. Chemical name: (RS)-2-(10-hydrogen-9-oxa-1-azaanthen-6-yl) propionic acid Molecular weight: C15H13NO3
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	0.1%(5ml:5mg)
Manufacturer	Guangdong Zhongsheng Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Wuhan Leadpharm Pharmaceutical Technology Co., Ltd.

China
Active
Gansu Haotian PharmaTech Co., Ltd.

China
Active
Shijiazhuang Lonzeal Pharmaceuticals Co., Ltd.

China
Active

See More Registered Holders

Recommended Suppliers of (±)-Pranoprofen

Hangzhou Dawn Ray Pharmaceutical Co.,Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of D-Biotin,Tobramycin base,L(-)-Carnitine base,Polymyxin B sulfate USP,Kanamycin sulfate monohydrate,Finasteride 99% USP

Pranoprofen china manufacture 99.0%min

CAS No.: 52549-17-4

Inquiry
HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Pranoprofen

CAS No.: 52549-17-4

Content: 99.00%

Inquiry
Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of PVC resin,pvc paste resin,melamine

high quality Pranoprofen 99% transparent liquid KANBEI

CAS No.: 52549-17-4

Grade: Industrial Grade

Content: 99%

Inquiry
Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals,CATALYST AND AUXILIARY,FLAVORS AND FRAGRANCES,Chemical Pesticides,ADDITIVE

Praprofen CAS 52549-17-4

CAS No.: 52549-17-4

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Hubei KDG Web Science&Technology Co.,Ltd Contact Supplier

CN
2 YRS

Business licensed

Trader Supplier of Peptide,API,HCG,Amino Acids,Plant Extract,Vitamin

Cheap Price High Quality Pranoprofen CAS 52549-17-4 Global Warehouse

CAS No.: 52549-17-4

Grade: Pharmaceutical Grade

Content: 99%

Inquiry