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Tak-715

Tak-715 structure

CAS No:
303162-79-0
Formula:
C24H21N3OS
Chemical Name:
Tak-715
Synonyms:
Tak-715;N-(4-(2-Ethyl-4-(3-methylphenyl)-thiazol-5-yl)pyridin-2-yl)benzamide;BenzaMide, N-[4-[2-ethyl-4-(3-Methylphenyl)-5-thiazolyl]-2-pyridinyl]-;N-(4-(2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl)-2-pyridyl)benzamide;N-(4-(2-Ethyl-4-(m-tolyl)thiazol-5-yl)pyridin-2-yl)benzamide
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1.IC50 value: 7.1 nM [1]Target: p38α MAPKin vitro: TAK 715 inhibits LPS-stimulated release of TNF-alpha from THP-1 with IC50 of 48 nM [1]. TAK 715 (10 μM) inhibits Wnt-3a-induced hDvl2 phosphorylation and the hDvl2 shift in U2OS-EFC cells [2]. The amide NH of TAK 715 is hydrogen bonded to the main-chain carbonyl of Met109 of p38 a

N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide is a member of benzamides.|TAK-715 is under investigation in clinical trial NCT00760864 (Safety and Efficacy of TAK-715 in Subjects With Rheumatoid Arthritis).

Tak-715 Basic Attributes

Molecular Weight：

399.52

Exact Mass：

399.140533

UNII：

WE92U03C5Z

DSSTox ID：

DTXSID20184412

Characteristics

PSA：

83.1

XLogP3：

5.6

Appearance：

faint yellow to dark yellow

Density：

1.2±0.1 g/cm3

Flash Point：

253.3±28.7 °C

Refractive Index：

1.656

Water Solubility：

DMSO: >15mg/mL

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

22-36

safety instructions：

Marks：

Precautionary statement(s)：

P305 + P351 + P338

Hazard Statements：

H302-H319

Drug Information

MeSH Entry Terms：

N-(4-(2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl)-2-pyridyl)benzamide

Computed Properties

Molecular Weight:399.5
XLogP3:5.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:399.14053348
Monoisotopic Mass:399.14053348
Topological Polar Surface Area:83.1
Heavy Atom Count:29
Complexity:538
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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TAK-715

CAS No.: 303162-79-0

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