4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine
-
![4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/ae670bb9306b420fa68c31422fa801e4.png "4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine")
4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine
structure -
-
CAS No:
71149-52-5
-
Formula:
C7H6ClN3
-
Chemical Name:
4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine
-
Synonyms:
1H-Pyrrolo[2,3-d]pyrimidine, 4-chloro-2-methyl-;4-chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine;2-methyl-4-chloro-pyrrolopyrimidine;4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine;4-Chloro-2-methyl-7H-pyrrolo
- Categories:
-
CAS No:
4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine Basic Attributes
167.6
167.025024
DTXSID70448334
2933990090
4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine Use and Manufacturing
A suspension of 90 mg (0.60 mmol) of the above hydroxypyrrolopyrimidine in 2 mL of phosphorous oxychloride was refluxed for 2 hours. The excess phosphorous oxychloride was removed and the residue was quenched carefully with ice. The mixture was extracted with ethyl acetate. The extracts were washed with brine, dried over MgSO2-Methyl-3H-pyrrolo[2, 3-d]pyrimidin-4(7H)-one 23-a (10.54 g, 70.6 mmol) was dissolved in Toluene (20 mL) under inert atmosphere. DIPEA (24 mL, 141 mmol, 2 eq.) and POC13 (19.5 mL, 212 mmol, 3 eq.) were added dropwise at 70°C and the mixture was then heated to 106°C. After 16 hours, the solution was concentrated in vacuo, extracted with ethyl acetate and washed with saturated NaHCO3 solution. Thecombined organic layers were dried over Na2504, and concentrated in vacuo to yield a grey oil which was suspended in water/heptanes to afford a white solid intermediate 23(5.9 g, 50percent).N-(4-methoxyphenyl)-N, 2-dimethyl-7H-pyrrolo[2, 3-d]pyrimidin-4-amine (AAG20); Compound 4 (0.005 mol, 0.835 g) was added to a solution of 4-methoxy-N-methylaniline (5, 0.006 mol, 0.822 g) in i-propanol (10 ml) with drops of conc. HCl. The resulting solution was transferred to a microwave vial (20 ml) and irradiated at 110° C. After 6 h, the reaction was completed and AAG20 was obtained after the chromatographic purification as a white solid (1.01 g) with 80percent yield. TLC RTo a solution of
Computed Properties
Molecular Weight:167.59
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:167.0250249
Monoisotopic Mass:167.0250249
Topological Polar Surface Area:41.6
Heavy Atom Count:11
Complexity:153
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine
-
![China]()
CN
5 YRS
Business licensed Certified factoryManufactory Supplier of fine chemicals,pharmaceutical materialsInquiryCAS No.: 71149-52-5Grade: industrial GradeContent: 98% -
![China]()
CN
5 YRS
Business licensed Certified factoryManufactory Supplier of Active Pharm Ingredients,Chemical Catalyst,Pharmaceutical Intermediates,Flavors and Fragrances,Agrochemicals,Chemical Pesticides,Organic Intermediates,OLED IntermediatesInquiryCAS No.: 71149-52-5Grade: Pharmaceutical GradeContent: 99%
Learn More Other Chemicals
-
(2E)-3-(1-METHYL-1H-PYRROL-2-YL)ACRYLIC ACID
51485-76-8
-
Benadryl N-oxide hydrochloride
13168-00-8
-
6-CHLORO-3-IODO-IMIDAZO[1,2-A]PYRIDINE
885275-59-2
-
(2-Bromophenyl)diphenylphosphine Formula
62336-24-7
-
1-Morpholinocyclopentene Formula
936-52-7
-
4-[2-(Boc-amino)ethoxy]-benzoic acid Formula
168892-66-8
-
3-amino-5-bromopyridine-2-carboxylic acid Structure
870997-85-6
-
2-Amino-6-methylpyridine Structure
1824-81-3
-
What is 3-Bromo-2-methylthiophene
30319-05-2
-
What is THIOPHEN-2-YLMETHYL-PHOSPHONICACIDDIETHYLESTER
2026-42-8
4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine
SDSRequest for Quotation