3-BROMO-2-METHYL-5-NITROPYRIDINE
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3-BROMO-2-METHYL-5-NITROPYRIDINE
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CAS No:
186593-42-0
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Formula:
C6H5BrN2O2
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Chemical Name:
3-BROMO-2-METHYL-5-NITROPYRIDINE
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Synonyms:
3-BROMO-2-METHYL-5-NITROPYRIDINE;3-Bromo-5-Nitro-2-Picoline;3-Bromo-2-methyl-5-nitrop...;2-Methyl-3-broMo-5-nitropyridine
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CAS No:
Characteristics
58.7
1.8
1.709±0.06 g/cm3(Predicted)
270.6±35.0 °C(Predicted)
117.4±25.9 °C
1.600
0.0113mmHg at 25°C
3-BROMO-2-METHYL-5-NITROPYRIDINE Use and Manufacturing
Step 3: To a cooled (15° C.) solution of diethyl malonate (8.8 mL; 58 mmol) in diethyl ether (110 mL) was added NaH (as a 60percent dispersion in oil; 2.32 g; 58 mmol) over 5 min and 3-bromo-2-chloro-5-nitropyridine (12.5 g; 52.6 mmol) in four portions over 15 min (an exotherm to 26° C. was observed), followed by removal of diethyl ether in vacuo to give a red oil. After stirring the resulting red oil at 114° C. for 1 h 15 min, HTo a cooled (15° C.) solution of diethyl malonate (8.8 mL, 58.0 mmol) in diethyl ether (110 mL) was added NaH (60percent dispersion in oil, 2.32 g, 58.0 mmol) over 5 min and 3-bromo-2-chloro-5-nitropyridine (12.5 g, 52.6 mmol) in four portions over 15 min (an exotherm to 26° C. was observed), followed by removal of diethyl ether in vacuo to give a red oil. After stirring the resulting red oil at 114° C. for 1 h 15 min, HStep 3: To a cooled (15° C.) solution of diethyl malonate (8.8 mL; 58.0 mmol) in diethyl ether (110 mL) was added NaH (as a 60percent dispersion in oil; 2.32 g; 58.0 mmol) over 5 min and 3-bromo-2-chloro-5-nitropyridine (12.5 g; 52.6 mmol) in four portions over 15 min (an exotherm to 26° C. was observed), followed by removal of diethyl ether in vacuo to give a red oil. After stirring the resulting red oil at 114° C. for 1 h 15 min, Hintothe mixture of Diethyl ether (30 ml) solution having diethyl Malonate (5 mmol)was added into the Sodium hydroxide (5 mmol)and stirred for 5mins. Again slowlyadded 3-bromo-2-cholro - 5- Nitropyridine (4.2mmol)and after stirring for 5 min the solvent was removed to give ared oily compound. At 114 ° C the oily mixture was stirred for 1.5 hours, 6Msulfuric acid (5.8 ml) and at reflux stirred for 8 hours. After cooling to 0 °C, with 25percent aqueous potassium hydroxide solution adjusted pH to 7 .theresulting precipitate was collected by filtration then it was washed with water and dried to give 0.65 g ofthe title compound
Computed Properties
Molecular Weight:217.02
XLogP3:1.8
Hydrogen Bond Acceptor Count:3
Exact Mass:215.95344
Monoisotopic Mass:215.95344
Topological Polar Surface Area:58.7
Heavy Atom Count:11
Complexity:159
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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