2-Chloro-4-methoxy-5-nitropyridine
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2-Chloro-4-methoxy-5-nitropyridine
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CAS No:
607373-83-1
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Formula:
C6H5ClN2O3
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Chemical Name:
2-Chloro-4-methoxy-5-nitropyridine
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Synonyms:
Pyridine,2-chloro-4-methoxy-5-nitro-;2-Chloro-4-methoxy-5-nitropyridine
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CAS No:
Safety Information
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
2-Chloro-4-methoxy-5-nitropyridine Use and Manufacturing
To a solution of A 0.5 L three-neck round-bottom flask, containing thermometer, water condenser and dropping funnel were charged with C-7C1 (10 g, 50.4 mmol, 1 eq), THF (50 mL) and methanol (200 mL). The whole mixture was stirred at 22 C for 10 min and then dimethylamine (13.7 mL, 60 % solution in water) was added dropwise. After 1 h a pale yellow solid started to precipitate. The next portion of dimethylamine (2 mL, 60 % solution in water) was added and the reaction was continued for an additional 24 h. After that time the reaction mixture was concentrated in vacuo and the crude material was suspended in methanol (70 mL) and water (140 mL). After vigorous stirring for 1 h at 0 C the pale yellow solid was filtered off, washed with a small amount of methanol-water solution and vacuum dried. As a result, compound C-7C2 was obtained as a pale yellow solid (10 g; 100 % yield; 99 % purity according to UPLCMS analysis).
Computed Properties
Molecular Weight:188.57
XLogP3:1.6
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:187.9988697
Monoisotopic Mass:187.9988697
Topological Polar Surface Area:67.9
Heavy Atom Count:12
Complexity:173
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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2-Chloro-4-methoxy-5-nitropyridine
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