6-Chloro-2-methyl-3-nitropyridine
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6-Chloro-2-methyl-3-nitropyridine
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CAS No:
22280-60-0
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Formula:
C6H5ClN2O2
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Chemical Name:
6-Chloro-2-methyl-3-nitropyridine
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Synonyms:
Pyridine,6-chloro-2-methyl-3-nitro-;2-Picoline,6-chloro-3-nitro-;6-Chloro-2-methyl-3-nitropyridine;2-Chloro-5-nitro-6-methylpyridine;2-Chloro-6-methyl-5-nitropyridine;3-Nitro-6-chloro-2-picoline;6-Chloro-3-nitro-2-picoline;NSC 75592;2-Chloro-5-nitro-6-picoline
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CAS No:
Characteristics
58.7
2
Light beige to brown Powder
1.4±0.1 g/cm3
54-55 °C
255.9°C at 760 mmHg
124.2±25.9 °C
1.576
0.00597mmHg at 25°C
Safety Information
IRRITANT
36/37/38-20/21/22-22
36/37/39-26
Xn,Xi
Harmful
P261, P264, P270, P271, P280, P301+P310, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P311, P312, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, P501
H301
|Danger|H301 (11.11%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P311, P312, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 9 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
6-Chloro-2-methyl-3-nitropyridine Use and Manufacturing
3-((5-Amino-6-methylpyridin-2-yl)ethynyl)-7, 7-dimethyl-7, 8-dihydroquinoone[00319] A mixture of 6-methyl-5-nitropyridin-2-ol (500 mg, 3.24 mmol), POCIThe raw material 3 (150 mg) and PCl(c) To 6-Hydroxy-3-nitro-2-picoline (15.73 g, 0.102 mol) was added PCls (5.73 g, 0.027 mol) and POCh (2.9 ml, 0.032 mol). This mixture was heated at 110-115°C for 3 hrs. However, the amount of POCh added was only enough to moisten the starting material. More POC13 (3 ml) was added, the reaction mixture heated at 110-115°C but only sublination of PCls (100°C) was observed. DMF (5 ml) was added and the solution was heated at 115°C for 5 hrs, cooled and poured into a slush of ice and water. A beige product precipitated and the water suspension was stirred for 48 hrs. The brown precipitate was filtered off and washed with water. Purification by dry-flash dichloromethane yielded 10.93 g (62 percent) of 6-chloro-2-picoline.B. To a solution of
Computed Properties
Molecular Weight:172.57
XLogP3:2
Hydrogen Bond Acceptor Count:3
Exact Mass:172.0039551
Monoisotopic Mass:172.0039551
Topological Polar Surface Area:58.7
Heavy Atom Count:11
Complexity:159
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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6-Chloro-2-methyl-3-nitropyridine
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