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Amifostine hydrate

Amifostine hydrate structure

CAS No:
63717-27-1
Formula:
C5H17N2O4PS
Chemical Name:
Amifostine hydrate
Synonyms:
AMIFOSTINE HYDRATE;2-((3-aminopropyl)amino)-ethanethiodihydrogenphosphate(ester)hydrate;phosphorothioicacid,s-(2-((3-aminopropyl)amino)ethyl)ester,hydrate;phosphorothioicacid,s-esterwith2-((3-aminopropyl)amino)ethanethiol,hydra;Amifostinum [INN-Latin];Phosphorothioic acid 2-((3-aminopropyl)amino)ethanethiol S-ester hydrate;Amifostina;Amifostina [inn-spanish]

Description

A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.

Amifostine hydrate Basic Attributes

Molecular Weight：

232.24

Exact Mass：

232.06500

UNII：

L693H6MM64

DSSTox ID：

DTXSID70213140

Characteristics

PSA：

122

XLogP3：

0.77760

Melting Point：

160-161° (dec)

Boiling Point：

441.7ºC at 760 mmHg

Flash Point：

220.9ºC

Toxicity：

Peritoneal-mouse LD50: 700 mg/kg; unnamed-mouse LD50: 375mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxides, phosphorus oxides and sulfur oxide fumes

Safety Information

Storage features：

Warehouse ventilated, low temperature and dry

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 39 companies from 1 notifications to the ECHA C&L Inventory.

Toxicity

Toxicity class：

moderately toxic

Drug Information

MeSH：

Drugs used to protect against ionizing radiation. They are usually of interest for use in radiation therapy but have been considered for other purposes, e.g. military. (See all compounds classified as Radiation-Protective Agents.)

MeSH Entry Terms：

Amifostine

Computed Properties

Molecular Weight:232.24
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:7
Exact Mass:232.06466520
Monoisotopic Mass:232.06466520
Topological Polar Surface Area:122
Heavy Atom Count:13
Complexity:152
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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Guide of Amifostine hydrate

Description
Basic Attributes
Characteristics
Safety Information
Toxicity
Drug Information
Computed Properties
Learn More Other Chemicals

Amifostine hydrate

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