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2-Amino-5-bromophenol

2-Amino-5-bromophenol structure

CAS No:
38191-34-3
Formula:
C6H6BrNO
Chemical Name:
2-Amino-5-bromophenol
Synonyms:
Phenol,2-amino-5-bromo-;2-Amino-5-bromophenol;4-Bromo-2-hydroxyaniline;5-Bromo-2-aminophenol
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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Description

white to light yellow solid

2-Amino-5-bromophenol Basic Attributes

Molecular Weight：

188.02

Exact Mass：

188.02

DSSTox ID：

DTXSID80558877

HScode：

2922299090

Characteristics

PSA：

46.2

XLogP3：

1.6

Appearance：

white to light yellow solid

Density：

1.8±0.1 g/cm3

Melting Point：

146-147 °C

Boiling Point：

265°C at 760 mmHg

Flash Point：

114.1±23.2 °C

Refractive Index：

1.677

Safety Information

hazard class code：

safety instructions：

36/37

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

2-Amino-5-bromophenol Use and Manufacturing

3-Bromo-6-nitrophenol (0.292 gms, 1. 34 mmole) was stirred in an 0.5percent aqueous sodium hydroxide solution (30 mL). Sodium hydrosulphite (2.00 gms of 85percent, 9.76 mmole) was added to the reaction flask and this was stirred at room temperature for 15 minutes. The reaction flask was then acidified with diluted hydrochloric acid until a pH of 5 was obtained. The reaction was then extracted three times with 40 mL portions of diethyl ether, the combined organic layers dried over anhydrous sodium sulfate, and concentrated to provide crude 2-amino-5-bromophenol (0.533 gms, m. p. 99.5-100. 5 C), which was recrystallized from ethyl ether/hexanes to provide the pure product (0.151 gms, 0.80 mmole, 60percent yield; m. p. 125-127 C (decompose) (reported m. p. 149.5-150. 5 C (Boyland, E et al., 1954) ;'H NMR (CD3CN, 500 MHz) 8 7.08 (bs, 1H), 6.82 (d, 1H, J= 2 Hz), 6.78 (dd, 1H, J= 8, 2 Hz), 6.56 (d, 1H, J= 8 Hz), 4.03 (bs, 2H); IR (KBr) 3496 (broad), 3377, 3298, 1598, 1502, 1431, 1269, 1210, 916, 877 cm'') 5aposINTERMEDIATE B3 2-Amino-5-bromophenol A suspension of iV-(4-bromo-2-hydroxyphenyl)acetamide (Intermediate B2; 1.35 g, 5.87 mmol) in EtOH (30 mL) and 3 M HCl (30 mL) was heated to 100

Computed Properties

Molecular Weight:188.02
XLogP3:1.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Exact Mass:186.96328
Monoisotopic Mass:186.96328
Topological Polar Surface Area:46.2
Heavy Atom Count:9
Complexity:99.1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 2-Amino-5-bromophenol

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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5 YRS

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2-Amino-5-bromophenol

CAS No.: 38191-34-3

Content: 99.00%

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Shanxi Hongruichang International Trade Co.，Ltd. Contact Supplier

CN
2 YRS

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2-Amino-5-bromophenol powder

CAS No.: 38191-34-3

Grade: Industrial Grade

Content: 98%

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